肠道病毒EV71引发脑干脑炎的细胞因子免疫发病机制研究进展

Progress of Study on Brainstem Encephalitis Cytokine Immune Pathogenesis Caused by EV 71

肠道病毒71型(EV71)是疱疹性咽峡炎和手足口病最重要的诱因之一,并能引发严重的中枢神经系统并发症,伴随着肺水肿的脑干脑炎可致死。细胞因子作为先天免疫的一部分,有利于抗病毒和Th1免疫反应的进行。细胞因子和炎症趋化因子在EV71脑干脑炎发病中起重要作用。在EV71肺水肿发病过程中,中枢神经系统和全身炎症应答对感染扮演重要但明显不同的角色。静脉滴注免疫球蛋白和磷酸二酯酶抑制剂,对EV71自主神经系统失调和肺水肿患者可以起到调节炎症、降低交感神经过度兴奋和提高存活率的作用。

Enterovirus 71 is one of the trigger factors for herpangina and hand -foot-and-mouth disease , which causes severe central nervous system complication with lethiferous brainstem encephalitis of pneumonedema . As a part of innate immunity cytokines support the antiviral and immune response to Th 1.Cytokines and chemokines play an important role in the pathogenesis of EV 71 brainstem encephalitis .It is obviously that the central nervous system and systemic inflammatory response play different roles in the disease progression of pneumonedema.For patients, who suffered from EV71 autonomic nervous systems disorders and pneumonedema , intravenous infusion of immunoglobulin and phoshodiesterase may serve to regulate inflammation , reduce sympathetic excessive stimulation and improve the survival rate .