姜黄素醇质体体外透皮及其稳定性研究

In vitro Transdermal Penetration and Stability of Curcumin Ethosomes

目的:对姜黄素醇质体体外透皮及其稳定性进行考察方法:采用透皮扩散仪进行体外透皮实验,比较姜黄素醇质体、溶液、脂质体经小鼠离体皮肤的累积渗透量及皮肤滞留量;并将姜黄素醇质体4℃条件下冷藏,考察其稳定性。结果:姜黄素醇质体12 h内单位面积皮肤的累计渗透量和皮肤滞留量是其溶液(含0.5%吐温-80)的2.71倍和2.81倍;但与其脂质体无显著差异。姜黄素醇质体4℃条件下冷藏1个月,其外观、包封率、粒径及多分散指数(PDI)变化较小。结论:醇质体作为透皮给药载体能促进姜黄素的透皮吸收,并能增加皮肤中的滞留量;姜黄素醇质体具有一定的稳定性。

Objective： To study the in vitro transdermal penetration and stability of curcumin ehosomes. Methods： The cumulative permeation amount and retention quantity in skin were compared among ethosomes, solutions and liposomes of curcumin by in vitro transdermal experiments. The stability of curcumin ethosomes was investigated under the condition of 4℃. Results： The 12-hour cu- mulative permeation amount and per unit skin retention quantity of curcumin ethosomes was 2.71 times and 2.81 times of the solutions （containing 0.5% Tween-80）, while those showed no significant difference from those of curcumin liposomes. The appearance, encapsulation efficiency, particle size and PDI of curcumin ethosomes exhibited little change after one month under the condition of 4℃. Conclusion： Ethosomes used as the transdermal carriers can promote the transdermal absorption and the skin retention of curcumin with promising stability.