石韦不同提取物的抗炎镇痛作用考察

Anti-inflammatory and Analgesic Effects of Different Extracts of Folium Pyrrosiae

目的:探讨石韦不同溶剂提取物的抗炎镇痛作用。方法:制备石韦水提取物和75%乙醇提取物,采用二甲苯致小鼠耳廓肿胀法观察其抗炎作用,采用醋酸扭体法和热板法观察其镇痛作用。结果:石韦醇提取物能明显抑制二甲苯所致小鼠耳廓肿胀(P<0.01),且具有抑制醋酸致小鼠扭体的作用(P<0.05),在给药后1 h、2 h均能提高热板法小鼠的痛阈值(P<0.05);石韦水提取物能抑制二甲苯所致小鼠耳廓肿胀和醋酸所致小鼠扭体的作用(P<0.05),在给药后1 h能提高热板法小鼠的痛阈值(P<0.05)。结论:石韦具有一定的抗炎镇痛作用。

Objective：To study the anti-inflammatory and analgesic effects of different solvent extracts of Folium Pyrrosiae. Meth-ods：Water extract and 75% alcohol extract of Folium Pyrrosiae were obtained. Mouse auricle swelling model induced by xylene was used to observe the anti-inflammation. The analgesic effect was tested by acetic acid writhing test and hot plate test. Results：The eth-anol extract of Folium Pyrrosiae could markedly inhibit the mouse auricle swelling induced by xylene （P〈0. 01）, and had the ability to inhibit the twisting induced by acetic acid in the mice （P 〈0. 05）. The ethanol extract of Folium Pyrrosiae could increase the threshold of pain in the mice significantly after the 1-hour and 2-hour treatment （P〈0. 05）. The water extract of Folium Pyrrosiae could inhibit the mouse auricle swelling induced by xylene and the writhing reaction induced by acetic acid （P〈0. 05）. The water ex-tract of Folium Pyrrosiae could increase the threshold of pain in the mice significantly after the 1-hour treatment （P〈0. 05）. Conclu-sion：Folium Pyrrosiae has obvious analgesic and anti-inflammatory effects.