摘要
目的:考察人工胃液对五味子甲素溶出率的影响,为五味子优选最佳提取方法提供参数。方法:用人工胃液提取五味子,用水提取法做对照,用高效液相色谱法测定提取物中的五味子甲素,比较两种溶剂对五味子甲素的溶出率。结果:60min时人工胃液提取溶出率为0.483%,水提法溶出率为0.362%。结论:人工胃液对五味子甲素的溶出率比水提取法高33.4%,能显著提高五味子甲素的溶出率。
Objective：To study the effect of artificial gastric juice on the dissolution of schizandrin A to provide the parameters for the best extraction method of Schisandra chinensis. Methods：Schisandra chinensis was respectively extracted by artificial gastric juice and water. Schizandrin A in the extracts was determined by HPLC, and the dissolution of schizandrin A in artificial gastric juice and water was studied and compared. Results：At 60 min, schizandrin A dissolution was 0. 483% in artificial gastric juice, and 0. 362%in water. Conclusion：The dissolution of schizandrin A in artificial gastric juice is 33. 4% higher than that in water, suggesting artificial gastric juice can significantly improve the dissolution of schisandrin A.
出处
《中国药师》
CAS
2014年第11期1837-1839,共3页
China Pharmacist
基金
太和科研基金资助项目(编号:2013JJXM021)
湖北省重大科学技术鉴定成果(登记号:EK2012D 150018000359)
关键词
五味子
人工胃液
溶出率
五味子甲素
Schisandra chinensis
Artificial gastric juice
Dissolution
Schizandrin A
