斑蝥酸钠维生素B_6注射液辅助治疗晚期宫颈癌疗效观察

Effect of Sodium Cantharidate Vitamin B_6 Injections in Adjuvant Treatment of Advanced Cervical Cancer

目的:探讨斑蝥酸钠维生素B6注射液辅助治疗晚期宫颈癌中的疗效。方法:60例晚期宫颈癌患者随机分为观察组和对照组,对照组采用常规放化疗,化疗方案为DP方案,观察组在对照组基础上加用斑蝥酸钠维生素B6注射液。6周后比较两组近期疗效、骨髓抑制不良反应、免疫功能和生活质量。结果:观察组近期疗效总有效率66.7%,显著高于对照组(40.00%,P<0.05);骨髓抑制不良反应程度显著低于对照组(P<0.05)。治疗后两组CD8+、NK细胞、CD8+/CD4+均较治疗前显著改善(P<0.05),且观察组改善优于对照组(P<0.05)。观察组生活质量改善率明显高于对照组(P<0.05)。结论:斑蝥酸钠维生素B6注射液辅助治疗可显著提高晚期宫颈癌患者的近期疗效和免疫功能,减少骨髓抑制,改善患者的生活质量。

Objective：To explore the effect of sodium cantharidate vitamin B6 injections in the adjuvant treatment of advanced cervical cancers. Methods：Totally 60 cases of advanced cervical cancer patients were randomly divided into the observation group and the control group, and the control group was given common DP chemotherapy and radiotherapy, while the observation group was given sodium cantharidate vitamin B6 injections additionally. After the 6-week treatment, the short-term curative effect, bone marrow inhibition adverse reaction, immune function and life quality were compared between the two groups. Results：The short-term curative effect in the observation group was 66. 7%, which was significantly higher than that in the control group （40%）（P〈0. 05）. The degree of adverse reaction was significantly lower than that in the control group with statistical significance （P〈0. 05）. After the treatment, CD8 ＋, NK cells and CD8 ＋ / CD4 ＋ in the two groups were significantly improved, and those in the observation group were all better than those in the control group （P〈0. 05）. The improvement of life quality in the observation group was more notable than that in the control group with statistical significance （P 〈0.05）. Conclusion： Sodium cantharidate vitamin B6 injections can significantly increase the short-term curative effect and immune function, decrease bone marrow inhibition and improve life quality of advanced cervical cancer patients.