糠酸莫米松鼻喷雾剂联合孟鲁司特治疗变应性鼻炎效果观察

Effect of Mometasone Furoate Nasal Sprays Combined with Montelukast on Allergic Rhinitis

目的:观察糠酸莫米松鼻喷雾剂与孟鲁司特联合治疗变应性鼻炎(AR)的疗效及预防复发作用。方法:74例AR患者随机分为观察组和对照组。观察组患者予糠酸莫米松鼻喷剂联合孟鲁司特片治疗,对照组患者仅予糠酸莫米松鼻喷剂治疗,两组疗程均为4周。观察并比较两组临床疗效及药品不良反应,随访1年后比较两组复发率。结果:观察组总有效率(94.59%)明显高于对照组(78.38%),1年内复发率(22.86%)明显低于对照组(48.28%),差异均有统计学意义(P<0.05)。两组药品不良反应发生率比较,差异无统计学意义(P>0.05)。结论:糠酸莫米松鼻喷剂联合孟鲁司特治疗AR疗效优于单用糠酸莫米松治疗,能降低AR复发率,且安全性好。

Objective： To observe the curative effect and reoccurrence prevention of mometasone furoate nasal sprays combined with montelukast on allergic rhinitis （ AR） . Methods：Totally 74 cases of patients with AR were divided into the observation group and the control at random. The patients in the observation group were given mometasone furoate nasal sprays combined with montelukast, while the patients in the control group were only given mometasone furoate nasal sprays for 4 weeks. The clinical curative effect and adverse drug reaction （ ADR） in the two groups were observed and compared, and the reoccurrence rates in the two groups after one-year following-up were compared as well. Results：The total efficiency in the observation group was 94. 59%, which was much higher than that in the control group （78. 38%）, and the reoccurrence rate in one year was 22. 86% in the observation group, which was much lower than that in the control group （48. 28%） with statistical differences （P〈0. 05）. After comparing the occurrence rate of ADR in the two groups, the difference was not statistically significant （P 〉0.05）. Conclusion： Compared with mometasone furoate nasal sprays, the application of mometasone furoate nasal sprays combined with montelukast in the treatment of AR can reduce the reoccurrence rate with good security.