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Lyn酶在非酒精性脂肪性肝炎组织Kupffer细胞中的表达及意义 被引量：2

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摘要 目的分析非酒精性脂肪性肝炎(NASH)组织Kupffer细胞中Lyn酶的表达及其临床意义。方法收集37例手术切除的肝组织石蜡标本,其中12例原发性肝癌癌旁正常肝组织,25例炎症反应明显的NASH组织。利用免疫组化法检测肝组织Kupffer细胞中Lyn酶的表达情况,并分析其阳性率与肝组织炎症的相关性。结果 25例NASH患者Lyn酶阳性表达25例,其中染色强度以上的23例(92%),Lyn阳性率与NASH的炎症程度呈正相关(P<0.05)。结论 Lyn的异常表达与肝脏炎症程度显著相关,检测其表达有助于NASH炎症程度的评价。
作者 刘先进 李民 张玲燕 肖锋 顾春燕 邵建国 陈琳 何红梅 孙燕
机构地区 南通大学附属南通第三医院 南通市第六人民医院 南京中医药大学第一临床医学院
出处 《江苏医药》 CAS 北大核心 2014年第21期2608-2610,F0002,共4页 Jiangsu Medical Journal
基金 江苏省自然科学基金(SBK2011394) 南通市社会发展计划项目(K11907 HS2013054)
关键词 非酒精性脂肪性肝炎 KUPFFER细胞 LYN 炎症
分类号 R512 [医药卫生—内科学]
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参考文献12

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同被引文献50

  • 1钱晓武,范竹萍,邱德凯.脂联素及受体与非酒精性脂肪性肝炎[J].国际消化病杂志,2006,26(3):157-160. 被引量：2
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江苏医药
2014年 第21期

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