基于药物代谢组学的个体化医疗研究进展

Progress in the personalized medicine using pharmacometabonomics

药物代谢组学作为系统生物学中的新兴学科,近年来逐渐被应用于个体化医疗并展现出广阔的前景。它通过代谢组学手段,描绘病人个体复杂细致的代谢轮廓,提供对疾病表型的更加详实的描述,并以此为依据,预测和评估不同个体对药物的反应能力,从而选择合适的药物和给药剂量,极大地促进了个体化治疗目标的实现。本文介绍了药物代谢组学这一新兴领域,并对近年来的基于药物代谢组学的个体化医疗研究成果进行了详细综述。

Pharmacometabonomics,as an emerging branch of system biology,has been increasingly used in personalized medicine and showed broad prospects. By means of metabonomics,the complicated and detailed metabolic profile of the patient is described,thus providing more detailed description of the disease phenotype. With this understanding,response of different individuals to the drugs are predicted or evaluated through inherent genetic information of the individual combined with the environmental factors. As a result,appropriate drugs and dosage are chosen,which greatly promotes the realization of the individualized therapy goals. This article describes the emerging field of pharmacometabonomics,and the research results of personalized medicine based on the pharmacometabonomics in recent years are reviewed in detail.