1540nm点阵激光辅以类人骨胶原敷料治疗痤疮后早期表浅凹陷性瘢痕的疗效观察

Evaluation efficacy of facial atrophic scar following treatment with 1540 nm fractional laser combined with human-like collagen dressings

目的：观察1540nm点阵激光辅以类人骨胶原敷料治疗痤疮后表浅凹陷性瘢痕的疗效。方法选择病程小于12个月,愈后留有表浅凹陷性瘢痕的痤疮患者60例,用1540点阵激光的各种不同治疗参数及能量进行治疗,激光治疗每次间隔1周,连续治疗4次。将患者随机分为实验组（36例）和对照组（24例）。实验组使用类人骨胶原敷料,对照组使用无纺布纯净水面膜,激光术后即刻敷用15-20min。每晚使用1次,每次15-20min,连续使用5d。结果实验组瘢痕治疗的有效率为91.67%,对照组的有效率为62.5%,实验组优于对照组,差异具有统计学意义（P〈0.05）。两组红斑治疗后临床评分差异无统计学意义（P〉0.05）。两组患者对保湿度、光滑度、满意度的评分差异有显著的统计学意义（P〈0.01）,实验组优于对照组。结论1540nm点阵激光无创伤,疼痛程度轻,术后不影响工作,辅以胶原蛋白敷料进行修复护理,无明显色素沉着及其他不良反应发生；患者依从性好,适用于对疼痛敏感且无时间休息的患者。

Objective To observe the effect of treatment that 1540 nm fractional laser combine with human-like collagen dressings superficial depressed scars after acne.Methods 60 patients with superficial depressed scars after acne were selected as subjects.All of them have less than one year disease course.1540 nm fractional laser was ap-plied for the treatment with a variety of different parameters and the energy.And laser treatment once every two weeks,continue for four times in all.Then patients were divided into experimental group （36 cases）and the con-trol group （24 cases ）.Test group use humanoid collagen dressings,non-woven pure water mask is used for control group immediately after laser treatment for 15 to 20 min.This treatment last for 15 to 20 min every night, which continue for 5 days.Results The efficiency of test group for scars is 91.67%,and effective rate of control group is 62.5%,the efficiency of experimental group is much better than the control group （P〈0.05）.No clini-cal difference between the two groups after treatment for erythema score （P 〉 0.05）.Satisfaction of patients in test group for moisture,smoothness is much higher than patients in control group （P 〈0.01）.Conclusion 1540 nm fractional laser has non-invasive and light pain,postoperative appearance has not effect for patients′work.At the same time,the treatment without the risk of pigmentation.When combined with human-like collagen dress-ings,there is no significant side effects and patient compliance is good.As a result,this kind of treatment is suit-able for patient who is sensitive to pain of has no time for rest.