来氟咪特在肾脏疾病中的合理应用

Rational application of leflunomide in kidney diseases

来氟咪特是一种抗增殖类的免疫抑制剂,主要作用机制为阻断嘧啶的从头合成,是临床治疗多种免疫介导性肾脏病的有效药物。近年来,基础研究结果发现来氟咪特还具有抗病毒和足细胞保护的作用,随着对其作用机制的深入研究,来氟咪特在糖尿病肾病、多瘤病毒相关性肾病和肝炎病毒相关性肾炎等的治疗中表现出独特的作用。此外,由于来氟咪特的治疗安全有效且价格适中也成为免疫抑制剂联合应用的有利选择。

Leflunomide is a kind of anti-proliferation immunosuppressive agent, whose main mechanism is blocking the de novo synthesis of pyrimidines, and is an effective drug for the clinical treatment of various immune-mediated kidney diseases. Besides, in recent years, results of basic researches have disclosed that leflunomide has antiviral and podocyte-protective effects. Leflunomide has also proved to have special effects in the treatment of diabetic nephropathy, polyomavirus-associated nephropathy, and hepatitis B virus-associated glomerulonephritis. The reason that leflunomide is both safe and effective with affordable price has made leflunomide a preferred choice for combined application of immunosuppressants.