急性冠脉综合征感染及炎性指标结果分析

Incidence of infection before the onset of acute coronary syndrome and the serum inflammatory indicators detection results analysis

目的:探讨急性冠脉综合征(ACS)患者血清中各项炎性指标的变化以及发病前感染的发生情况。方法:选取ACS患者83例为研究组,稳定型心绞痛患者或造影阴性的冠心病患者71例为对照组。分析患者临床资料,并比较其血清C-反应蛋白(CRP)、白介素-6(IL-6)以及可溶性P-选择素(Sp-sel)水平。结果:1研究组与对照组发病前感染率分别为41.0%和25.4%,研究组高于对照组(χ2=4.170,P<0.05);且年龄>70岁的患者发病前感染的概率明显高于年龄≤70岁的患者(χ2=3.645,P<0.05)。2研究组患者血清中CRP、IL-6和Spsel水平分别为(7.52±1.62)mg/L、(247.55±62.17)ng/L和(90.14±23.71)mg/L,均显著高于对照组,差异有统计学意义(t=21.556、18.391、14.091,P<0.05)。结论:ACS与发病前急性感染可能存在相关性,且ACS患者血清中的炎性指标明显升高,提示临床可以通过对患者炎性指标的检测对ACS进行预测。

Objective：To investigate the serum inflammatory indicators in acute coronary syndrome （ACS） and the incidence of infection before the onset of ACS. Method： Eighty three patients with ACS were chosen as the study group, and 71 patients with stable angina or coronary angiography negative were chosen as control group. clinical data were analyzed, the serum C-reactive protein （CRP）, interleukin-6 （IL-6） and soluble P-selectin （Sp- sel） levels were compared. Rcsult：①The infection rate before the onset of study group was 41.0%, which was higher than that of patients （5.4 % ）, and the difference was statistically significant （χ2 = 4. 170, P〈0.05）. And The infection rate before the onset in the patients with age〉 70 years was significantly higher than that in the pa- tients aged ≤ 70 years of age, and the difference was statistically significant （χ2= 3. 645, P〈0.05）. ②Serum CRP,IL-6 and soluble Sp-sel levels in study group were （7.52±1.62） mg/L, （247.55±62.17） ng/L and （90.14 ± 23.71） mg/L, which were significantly higher than those in the control group, and the differences were statisti- cally significant （t=21. 556,18. 391,14. 091,P〈0.05）. Conclusion：ACS and acute infection prior to the onset of may be correlated, and the ACS patients serum inflammatory markers were significantly increased, suggesting thatACS could be predicted by the inflammatory markers detection of patients.