2013年南京及周边地区新生儿溶血病统计分析

Statistical analysis on results of heamolytic disease of the newborn in the downtown,suburb and surrounding area of NanJing

目的:了解2013年南京市区、郊区及周边地区新生儿溶血病发病情况。方法:对2013年南京市区、郊区及周边地区14家医院送检的1 430例疑似新生儿溶血病的血液标本检测结果进行分析。结果:1 430例标本主要来源于南京市区3家医院,其次为郊区及周边地区。新生儿溶血病总的阳性率为33.3%,市区医院阳性率低于郊区及周边地区。新生儿溶血病主要以ABO血型系统溶血为主,南京市区3家医院溶血血型系统种类较多;ABO血型系统溶血阳性标本中,母亲血清抗体效价>1∶64的占29.4%,其中周边地区的比例最高。另有检出13例C3d阳性标本。结论:新生儿溶血病是一种免疫性溶血性疾病,当新生儿出现黄疸症状或母子血型不合但未出现黄疸时,应及时送检,及早确定是否是新生儿溶血病,达到早发现早治疗的目的,对于新生儿生存以及生长发育有益无害。

Objective：To investigate the situation of heamolytic disease of the newborn （HDN） in the down- town, suburb and surrounding area of Nanjing. Method： The results of HDN samples from 14 hospitals in the downtown, suburb and surrounding area of Nanjing were analyzed. Result： The main sources of 1 430 samples were 3 hospitals in the downtown of NanJing. The positive rate of HDN was 33.3%. The positive rate of HDN in downtown was lower than that in suburb and surrounding area. The main type of hemolysis was ABO blood sys- tem hemolysis. There were more blood system types hemolysis in the downtown. The percentage of mothers＇ ser- um antibody titer （titer〉 1： 64） was 29.4%. The highest percentage was from surrounding area. Beside these, there were 13 samples with Cad（＋） and 8 samples which had Rh（--） mothers but Rh（＋） babies and 1 sample with Rh（--） mother and baby. Conclusion： HDN was an immune hemolytic disease. When neonatal jaundice or blood type incompatibility happened, the newborn must take the test of HDN. So that, the newborn could receive timely treatment.