老年妇女股骨粗隆间骨折后雌激素水平与骨密度值的相关性研究

Correlation analysis of estrogen levels and bone mineral density values in the older women after intertuberosity fracture

目的探讨老年妇女股骨粗隆间骨折后雌激素水平与骨密度值的相关性。方法随机选择我院骨科于2009年9月至2013年8月间收治的老年妇女股骨粗隆间骨折患者90例,其中骨质正常组42例、骨量减少组28例、骨质疏松组20例。检测所有患者粗隆间骨密度与血清雌二醇(estradiol,E2),并进行相关性分析。结果术前、术后骨质正常组的骨密度T值均明显高于其他两组,三组间比较差异有统计学意义(P<0.05),但各组内手术前后的骨密度T值比较,差异无统计学意义(P>0.05);术前、术后骨质正常组的血清E2值均明显高于其他两组,三组间比较差异有统计学意义(P<0.05);三组术后的血清E2值都明显提高,各组内术后与术前血清E2值比较,差异均有统计学意义(P<0.05);Pearson相关分析结果显示雌激素水平与骨密度T值之间存在正相关性(r=0.358,P<0.05)。结论老年妇女雌激素水平的降低多伴有局部性骨密度降低,促使骨质疏松的发生,是股骨粗隆间骨折发病的危险因素。

Objective To explore the correlation of estrogen levels and bone mineral density values in the older women after intertuberosity fracture.Methods Ninety older women with inter tuberosity fracture were selected from Sep.2009 to Aug.2013 in our hospital,including 42 cases of the normal bone group,28 cases of osteopenia group,and 20 cases of osteoporosis group.All patients underwent intertrochanteric detection of bone mineral density and serum estradiol （E2） and the correlation analysis was done.Results The mineral density T-score in the normal bone group before and after operation was significantly higher than the other two groups （P＜0.05）,and the intra-group comparison showed no significant difference before and after operation （P＞0.05）.The serum E2 values in the normal bone group before and after operation were significantly higher than the other two groups （P＜0.05）,the postoperative serum E2 values in the three groups were significantly increased,and the intra-group comparison showed significant difference before and after operation （P＜0.05）.Pearson correlation analysis showed that the serum E2 levels were positively correlated to the T-score （r =0.358,P＜0.05）.Conclusion The older women have lower serum E2 levels that were combined with lower localized bone density,which is the risk factors for promoting the occurrence of osteoporosis and to the formation of intertrochanteric fractures.