猪离体心脏冠状动脉的MSCT造影

Coronary Angiography of in vitro Porcine Heart Using MSCT

目的通过对猪离体心脏冠状动脉进行多层螺旋CT(MSCT)造影成像,探索离体心脏血管造影技术的具体操作方法及参数。方法应用自主改装的血管造影装置,分别将脂溶性和水溶性对比剂以不同灌注量(50、60、70mL)和不同灌注-成像时间间隔(5、10、20min)灌注猪离体心脏冠状动脉,进行MSCT扫描和三维图像效果比较,由2名放射科医生对各组的造影成像效果进行评估和记录,并对结果进行统计学分析。结果脂溶性对比剂对冠状动脉周围脂肪造成浸润和破坏而影响造影成像效果,而水溶性对比剂未出现类似结果。灌注-成像时间间隔为5min,且灌注量为60mL和70mL时造影成像质量最佳。结论本研究的血管造影参数为后期开展尸体在体心脏冠脉造影奠定基础。

Objective To establish standardized methods and parameters of the isolated heart coronary an- giography through the experiment of in vitro porcine heart by MSCT. Methods Based on different perfu- sion volume （50, 60 and 70mL） and different perfusion-imaging time （5, 10 and 20min）, the in vitro porcine coronary artery was injected liposoluble and water-soluble contrast agents using remodel angiog- raphy equipment and scanned by MSCT. And the 3D image results were compared. The images were recorded and evaluated by 2 radiologists and analyzed by statistical soft-ware. Results Liposoluble con- trast agent affected the images by damaging and infiltrating the fats around the coronary artery, while the water-soluble contrast agent didn＇t affect the images. The groups with 60 mL or 70 mL perfusion and 5 min perfusion-imaging time had the best images. Conclusion The suitable parameters of the an- giography lay the foundation of postmortem coronary angiography.