双手第1骨间背侧肌代谢物的氢质子磁共振波谱

1H-MRS Study on the Metabolites of First Dorsal Interossei

目的探讨氢质子磁共振波谱(1H-magnetic resonance spectroscopy,1H-MRS)检测技术在尺神经损伤预后评估的应用前景。方法对12例健康青年志愿者、1例尺神经完全损伤者双手第1骨间背侧肌的代谢物进行1H-MRS检测,对采集到的数据进行统计分析。结果健康女性成年人第1骨间背侧肌的细胞外脂质(extra-myocellular lipids,EMCL)峰下面积高于男性(P<0.05),胆碱、肌酸、细胞内脂质(intramyocellular lipids,IMCL)在两性间差异均无统计学意义(P>0.05),双手间各峰下面积差异均无统计学意义(P>0.05)。尺神经损伤者患侧EMCL峰较健侧偏高,且FDI面积缩小。结论 1H-MRS对肌肉代谢物的无创性以及定量检测对周围神经损伤的预后评估具有一定价值。

Objective To estimate the application of prognosis evaluation of ulnar nerve injury by 1H- magnetic resonance spectroscopy （1H-MRS）. Methods The metabolites of first dorsal interossei （FDI） of two hands from 12 healthy volunteers and 1 volunteer with complete ulnar nerve injury were detected by tH-MRS and the data were statistically analyzed. Results For the FDI of healthy adults, the female peaks area of extra-myocellular lipids （EMCL） was higher than the male （P〈0.05）; There was no sig- nificant difference in Cho, Cr and intra-myocellular lipids （IMCL）between male and female （P〉0.05）; There was no significant difference in all the peaks area between the left and right hand （P^0.05）. The EMCL peak of the injury side was higher than that of the healthy side, and the area of FDI was reduced in the volunteer with ulnar nerve injury. Conclusion Noninvasive and quantitative detection of 1H-MRS may be valuable for prognosis evaluation of peripheral nerve injury.