高危型人乳头状瘤病毒生殖道感染与宫颈糜烂的相关性分析

Correlation between genital tract infection caused by high-risk human papillomavirus and cervical erosion

目的探索讨论高危型人乳头状瘤病毒(HR-HPV)感染与宫颈糜烂的相关性,为宫颈糜烂的预防和治疗提出理论依据,以预防更严重的病变发生。方法随机选取2012年5月-2013年6月收入的92例宫颈糜烂患者作为研究对象,利用二代杂交法对收集的宫颈脱落细胞进行检测,将患者的感染程度进行分度分型并对数据做统计学分析。结果宫颈糜烂Ⅰ、Ⅱ、Ⅲ度患者分别为25、37、30例,HR-HPV的感染率分别为12.0%、35.1%、46.7%;单纯型宫颈糜烂的25例患者中5例HR-HPV感染,颗粒型宫颈糜烂的37例患者中9例HR-HPV感染,乳头型宫颈糜烂的30例患者中13例HR-HPV感染,HR-HPV感染率与宫颈糜烂的不同程度的差异有统计学意义(P<0.05),而宫颈糜烂不同类型的HR-HPV感染的阳性率之间差异无统计学意义。结论 HR-HPV的感染与宫颈糜烂有着很密切的关系,密切关注宫颈糜烂患者是否感染HR-HPV,并针对性地治疗以防止癌变。

OBJECTIVE To explore the relationship between the high‐risk human papillomavirus （HR‐HPV） infec‐tion and the cervical erosion so as to provide theoretical basis for prevention and treatment of the cervical erosion and to prevent more severe lesions .METHODS A total of 92 patients with cervical erosion ,who were treated in the hospital from May 2012 to Jun 2013 ,were randomly recruited as the study objects ,then the collected cervical ex‐foliated cells were detected by using the second generation hybridization method ,the severity of the infections in the patients was classified ,and the data were statistically analyzed .RESULTS There were 25 cases of cervical ero‐sion of degree Ⅰ ,37 cases of cervical erosion of degree Ⅱ ,and 30 cases of cervical erosion of degree Ⅲ ,with the incidence rates of HR‐HPV infection of 12 .0% ,35 .1% ,and 46 .7% ,respectively .The HR‐HPV infection oc‐curred in 5 of 25 cases of single cervical erosion ,9 of 37 cases of particle type of cervical erosion ,and 13 of 30 ca‐ses of papillary cervical erosion ,there was statistically significant difference between the incidence rate of HR‐HPV infection and the different severities of cervical erosion （P〈0 .05） ,but there was no statistically significant difference in the positive rate of HR‐HPV infection between the patients with different severities of cervical ero‐sion .CONCLUSIONS The HR‐HPV infection is closely associated with the cervical erosion .It is necessary to pay close attention to the incidence of HR‐HPV infection in the patients with cervical erosion and conduct targeted treatment so as to prevent the carcinogenesis .