慢性阻塞性肺疾病患者血清晚期氧化蛋白产物水平变化的临床研究

Clinic study of serum product advanced oxidation protein changes of patients with chronic obstructive pulmonary disease

目的 检测慢性阻塞性肺疾病（COPD）患者血清晚期氧化蛋白产物（AOPP）的水平,探究AOPP与COPD的相关性及其临床意义.方法 纳入2011年4月至2013年11月来我院就诊的54例轻、中度COPD患者（COPD组）;同期收集30名健康志愿者作为健康对照组,两组一般情况相匹配.分别检测血清AOPP、超氧化物歧化酶（SOD）和丙二醛（MDA）的水平.结果 健康对照组血清AOPP为（45.78±12.54） μmol/L、MDA为（2.96±0.55） μmol/L、SOD为（78.40±8.37） kU/L,COPD组血清AOPP为（68.93±10.62） μmol/L、MDA为（6.07±2.44） μmol/L、SOD为（53.66 ±5.99） kU/L,两组比较差异均有统计学意义（t值分别为-8.57、-9.14、14.38,P均＜0.01）.轻度COPD组患者血清AOPP为（65.56±9.65） μmol/L、MDA为（4.21±1.83） μmol/L、SOD为（62.97 ±6.28） kU/L,中度COPD组血清AOPP为（71.79±11.37） μmol/L、MDA为（7.43 ±3.12） μmol/L、SOD为（41.25 ±5.89） kU/L,两组比较差异均有统计学意义（t值分别为-2.17、-4.80、13.00,P＜0.05或P＜0.01）.结论 血清AOPP水平增高是COPD患者的重要病理变化,可能参与COPD的发生及发展过程,是反映COPD患者氧化应激损伤的早期敏感指标.

Objective To investigate the serum levels of advanced oxidation protein products （AOPP） in patients with chronic obstructive pulmonary disease （COPD） as well as explore the relevance of its clinical significance AOPP and COPD.Methods Fifty-four patients with mild/moderate COPD （COPD group） were enrolled in this study,who were treated in the No.100th Hospital of the Chinese People＇s Liberation Army from Apr.2011 to Nov.2013.Thirty healthy volunteers （control group） at same period were selected as control group and the general condition of two groups were matched.AOPP,superoxide dismutase（SOD） and malondialdehyde （MDA） levels were measured.Results The serum AOPP,MDA and SOD in control group were （45.78 ± 12.54） μmol/L,（2.96 ± 0.55） μmol/L and （78.40 ± 8.37） kU/L respectively.And its were （68.93 ± 10.62） μmol/L,（6.07 ± 2.44） μmol/L and （53.66 ± 5.99） kU/L respectively in COPD group.The differences were statistically significant （t =-8.57,-9.14,14.38 ; All P values were less than 0.01）.The serum AOPP,MDA and SOD in mild COPD group were （65.56 ±9.65） μmol/L,（4.21 ± 1.83） μmol/L and （62.97 ± 6.28） kU/L respectively,and （71.79 ± 11.37） μmol/L,（7.43 ± 3.12） μmol/L and （41.25 ± 5.89） kU/L respectively in moderate CODP group.The differences were statistically significant （t =-2.17,-4.80,13.00; P ＜ 0.05 or P ＜ 0.01）.Conclusion The increased levels of serum AOPP is important pathological changes in patients with COPD,which may be involved in the occurrence and development of COPD,and is the reaction of oxidative stress injury in patients with COPD early sensitive indicator.