人类免疫缺陷病毒-1整合酶抑制剂的研究进展

Research Progress in HIV-1 Integrase Inhibitors

目的对人类免疫缺陷病毒-1整合酶抑制剂的最新研究情况进行综述。方法根据国内外文献报道,对已上市的3种人类免疫缺陷病毒-1整合酶抑制剂药物和新作用机制的整合酶抑制剂的研究情况进行归纳总结。结果与结论整合酶是人类免疫缺陷病毒-1病毒复制周期必需的基本酶之一,是新型抗艾滋病药物的作用靶点。随着人类免疫缺陷病毒耐药现象变得严重,整合酶抑制剂作为新作用机制的艾滋病治疗药物为临床提供了新的选择,新靶点和多靶点整合酶抑制剂的研发也使得未来人类免疫缺陷病毒治疗有更好的前景。

OBJECTIVE To review the latest research progress in HIV-1 integrase inhibitors.METHODS The research progress of the three marketed integrase inhibitor drugs and the integrase inhibitors with new mechanism were summarized according to the related articles.RESULTS AND CONCLUSION HIV-1 integrase as a novel target of new anti-AIDS drugs is one of the most essential enzymes for viral replication cycle.With the drug resistance of HIV becoming serious,integrase inhibitors as the new anti-AIDS drugs which have new mechanism of action can provide more choices to clinic.The research and development of integrase inhibitors with novel target and multiple targets have better prospect in the treatment of HIV.