摘要
目的建立新唑漱口液微生物限度检查方法。方法采用2010年版《中国药典》(二部)附录"微生物限度检查法"项下相关内容进行方法学验证。结果该漱口液对白色念珠菌和黑曲霉菌无抑制作用;薄膜过滤法可消除该药物对金黄色葡萄球菌、大肠埃希菌、枯草芽孢杆菌的抑制作用,回收率达75%以上。结论经方法学验证,结果符合现行《中国药典》2010年版的要求。
OBJECTIVE To establish a method to test microbial limit in Neomycin and Metronidazole garga- rism. METHODS Microbial limits test in Chinese Pharmacopoeia 2010 （section 2） appendix verified methodology was used. RESULTS The durg had no inhibitory action to white beads bacterium and aspergillus, and Membrane filtration method can eliminate the drug on staphylococcus aureus, e. coli, bacillus subtilis inhibitory effect. The recov- ery can reach up to 75 %. CONCLUSION Through the technological validation, the result is consistent with the re- quirement of ChP. （edition 2010） in force.
出处
《海峡药学》
2014年第10期51-53,共3页
Strait Pharmaceutical Journal
关键词
新唑漱口液
微生物限度检查
验证
Neomycin and Metronidazole gargarism
Microbial Limit
Validation
