尘肺合并肺部感染者高敏C反应蛋白与肺动脉压相关性的研究

The relationship between high-sensitive C-reactive protein and pulmonary arterial pressure among patients with pneumoconiosis combined with infection

目的观察尘肺合并肺部感染者在肺功能不同程度损伤时,血清高敏C反应蛋白(hs-CRP)与肺动脉收缩压(PASP)的变化,探讨二者相互关系及临床意义。方法采用回顾性研究的方法将93例尘肺合并肺部感染者按肺功能损伤程度分成正常、轻度损伤、中度损伤和重度损伤4组,分别对各组PASP和hs-CRP进行分析。结果在4组肺功能损伤程度不同的尘肺合并肺部感染者中,PASP和hs-CRP水平差异有统计学意义(P<0.05),其中重度损伤组分别为(127.07±56.50)mg/L和(59.10±14.00)mm Hg明显高于其他组(2.69±1.66)mg/L和(36.50±3.54)mm Hg、(2.10±10.50)mg/L和(33.13±12.60)mm Hg、(28.72±30.24)mg/L和(35.30±16.10)mm Hg(P<0.05);血清hs-CRP水平与PASP呈正相关(rs=0.71,P<0.01)。结论尘肺合并肺部感染者的血清hs-CRP水平分别与肺功能受损程度及肺动脉压存在关联。动态监测患者的血清hs-CRP变化有利于对病情的监控。

Objective To explore the relationship between high -sensitive C -reactive protein （hs -CRP）and pulmonary arterial systolic pressure （PASP）among patients with pneumoconiosis combined with infection in different degrees of pulmonary dysfunction status.Methods By retrospective study,93 pneumoconiosis patients combined with infection were divided into four groups according to their degree of pulmonary dysfunction.The relationship between PASP and hs -CRP was then analyzed.Results Pulmonary arterial systolic pressures and the serum levels of hs -CRP were significantly different among four groups （P 〈0.05）.Moreover pulmonary arterial systolic pressures and the serum levels of hs -CRP in severe group were higher than those of the other groups （all P 〈0.05 ）.The serum levels of hs -CRP were positively correlated with pulmonary artery systolic pressure （rs =0.71 ,P 〈0.01 ）.Conclusion The serum levels of hs -CRP are highly correlated with pulmonary arterial systolic pressures in patients with pneumoconiosis combined with infection.The serum levels of hs -CRP can reflect changes in pulmonary artery systolic pressure in some extent.