2266例0-16岁儿童维生素D营养状况调查与分析

Analysis of 25-hydroxy vitamin D levels in 2 266 cases of children at 0-16 years old in Nanjing area.

目的了解0-16岁儿童维生素D营养状况。方法对在南京儿童医院儿童保健科门诊进行常规体检的0-16岁2 266例儿童采用酶联免疫法进行血清25-（OH）D检测。结果1）冬春季检测1 204例,血清25-（OH）D为（55.1±19.58）nmol/L,男778例,女426例,血清25-（OH）D分别为（55.2±20.83）和（55.0±19.95）nmol/L,差异无统计学意义;其中≤1岁组、1-7岁组和〉7岁组血清25-（OH）D分别为（71.7±27.39）、（59.6±18.25）和（46.9±14.97）nmol/L,组间两两比较均有统计学意义（P〈0.01）。2）夏秋季检测1 062例,血清25-（OH）D为（67.2±46.89）nmol/L,男670例,女392例,血清25-（OH）D分别为（67.8±51.51）和（68.3±35.21）nmol/L,差异无统计学意义;其中≤1岁组、1-7岁组和≥7岁组,血清25-（OH）D分别为（98.0±39.97）、（73.0±61.73）和（55.8±16.75）nmol/L,组间两两比较差异均有统计学意义（P〈0.01）。3）日照不足的冬春季儿童的血清25-（OH）D水平显著低于日照充足的夏秋季（P〈0.01）。结论0-16岁儿童除夏秋季婴儿组外,其余各年龄组全年的维生素D营养状况均属于不足的水平,并且年龄越大,维生素D水平越低,应该增加南京市儿童维生素D摄入量及延长户外活动时间,尤需重视7岁以上儿童及冬春季维生素D的补充。

Objective To investigate the levels and deficiency of 25-hydroxy vitamin D[25-（OH）D] in children at 0n 16 years old in Nanjing area. Method Serum levels of 25-（OH）D in 2 266 cases of children at 0-16 years old,detected by enzyme linked immunosorbent assay （ELISA） between April 2012 and March 2013,were statistically analyzed. Results 1） Among 1 204 cases of children in winter and spring,the serum level of 25-（OH）D was （55.1±19.58）nmol/L （male 778,female 426）,there had no statistical difference between different gender groups. And there had statistical difference among group lower than 1 year old [（71.7±27.39）nmol/L] ,group 1-7 years old[（59.6±18.25）nmol/L] and group more than 7 years old[（46.9±14.97）nmol/L]. 2） Among 1 062 cases of children in summer and autumn, the serum level of[25- （OH）D] was （67.2±46.89） nmol/L （ male 670,female 392 ）,there had no statistical difference between different gender groups. And there had statistical difference among group lower than 1 year old [-（98.0± 39.97）nmol/L], group 1 - 7 years old [（73.0±61.73）nmol/L] and group more than 7 years old [（55.8±16.75）nmol/L]. 3）There had statistical difference between different season groups （P〈0.01）. Conclusion The serum levels of 25-（OH）D of 0-16 years old are sub clinic deficiency except group lower than 1 year old in Summer and Autumn. And the serum levels of 25-（OH）D decrease gradually by the age of children increasing.