摘要
为开发一种性能好且副作用少的抗酸剂,将氢氧化钙负载于酸活化蒙脱石上,然后用硬脂酸进行表面修饰,制备氢氧化钙/蒙脱石抗酸剂。考察Ca(OH)2负载量、负载温度及硬脂酸用量对抗酸剂体外抗酸和胃粘膜保护性能的影响。结果表明,制备氢氧化钙/蒙脱石抗酸剂的最适宜条件为:Ca(OH)2负载量37%,负载温度75℃,硬脂酸用量0.5 wt%。在最适宜条件下制备得到的抗酸剂在体外抗酸过程中维持pH>3超过1 h,小鼠溃疡抑制率为71.7%,其抗酸和胃粘膜保护性能与铝碳酸镁相当,但其抗酸过程不释放二氧化碳和镁铝离子。研究结果可为该抗酸剂进行临床实验奠定基础。
In order to develop an antacid with excellent acid resistant property and few side effects, calcium hydroxide/montmorillonite antacid was prepared by supporting calcium hydroxide on acid-activated montmorillonite and modification its surface with stearic acid.The effects of Ca ( OH ) 2 loading, load temperature and stearic acid dosage on the in-vitro acid resistant property and gastric mucosal protective effect of the antacid were investigated, and the antacid was compared with com-mercially available hydrotalcite antacid.The results showed that the optimum conditions for prepar-ing calcium hydroxide/montmorillonite antacid were Ca(OH)2 content 37%, load temperature 75℃and stearic acid dosage 0.5 wt%.By using the antacid prepared in the optimum conditions, the time of in-vitro acid resistance with pH>3 was more than 1 h and the ulcer inhibition rate of mice reached 71.7%, and the antacid was similar to commercially available hydrotalcite antacid in both acid resistant property and gastric mucosal protective effect.In addition, the antacid did not release CO2 , Mg2+and Al3+in the process of in vitro acid resistance.The research laids a foundation for the clinical trial of the antacid.
出处
《广西大学学报(自然科学版)》
CAS
北大核心
2014年第5期1186-1190,共5页
Journal of Guangxi University(Natural Science Edition)
基金
国家自然科学基金资助项目(21166004)
关键词
氢氧化钙
蒙脱石
抗酸剂
制备
calcium hydroxide
montmorillonite
antacid
preparation