IL-23、IL-17及IL-10变化与COPD及BODE指数的相关性研究

Correlation of the changes of IL-17,IL-23 and IL-10 to the indexes of COPD and BODE

目的探讨慢性阻塞性肺疾病稳定期患者痰中IL-23、IL-17及IL-10变化及其与BODE指数的关系。方法所有志愿者接受体重、身高、肺功能、呼吸困难程度、6分钟步行实验测量以BODE评分,用ELASA法检测36名慢性阻塞性肺疾病稳定期患者及22名健康对照组诱导痰中IL-23、IL-17及IL-10。结果与健康对照组相比,COPD稳定期患者IL-23、IL-17升高(P<0.05),IL-10降低(P<0.05);COPD稳定期患者痰中IL-23、IL-17与BODE指数正相关,IL-10与BODE指数负相关(rs分别为0.670、0.609、-0.526,P<0.05)。结论 IL-17、IL-23、IL-10可能参与COPD的发病,且IL-17、IL-23与病情的严重程度正相关,IL-10与病情的严重程度负相关。检测IL-17、IL-23、IL-10水平有助于评估COPD的疾病严重程度。

Objective To explore the correlation of the changes of IL-17, IL-23 and IL-10 to the indexes of COPD and BODE. Methods All volunteers ’ height, weight, lung function, modified medical research council （ MMRC） and six-minute walking distance were collected for estimating BODE index. Induced sputum samples were collected from 36 patients with COPD and 22 healthy people. The levels of IL-23, IL-17and IL-10 were measured by ELISA. Results The levels of IL-23 and IL-17 increased more significantly, and the level of IL-10 decreased more obviously in COPD patients than in the healthy controls （ P〈0. 05 ） . The levels of IL-23 and IL-17 were positively related with the indexes of BODE, and the level of IL-10 was negatively related with the indexes of BODE in COPD patients at stable stage. Conclusion IL-17,IL-23 and IL-10 may play important roles in the pathogenesis of COPD. The detection of IL-17, IL-23 and IL-10 can help to evaluate the severity of COPD.