降钙素原检测在儿童CAP中的早期诊断价值

Diagnostic value of procalcitonin detection in children with community-acquired pneumonia

目的探讨血清降钙素原(PCT)在儿童社区获得性肺炎(CAP)中的早期诊断价值。方法检测60例细菌性肺炎患儿(细菌性肺炎组),60例肺炎支原体肺炎患儿(肺炎支原体肺炎组)和30例病毒性肺炎患儿(病毒性肺炎组)及30例健康儿童(对照组)的血清PCT及C-反应蛋白(CRP)水平及白细胞计数(WBC),比较各组血清PCT和CRP水平及WBC结果。结果 CAP患儿血清PCT及CRP水平及WBC计数均明显高于对照组(P<0.05);细菌性肺炎组血清PCT及CRP浓度及WBC计数均明显高于肺炎支原体肺炎组、病毒性肺炎组(P<0.05)。CAP患儿PCT的ROC曲线下面积明显高于CRP(P<0.05)。结论血清PCT在CAP患儿中的鉴别诊断价值优于CRP。

Objective To study the role of the procalcitonin （ PCT） detection in the early diagnosis of com-munity-acquired pneumonia in children. Methods The levels of PCT, CRP and WBC were detected in 60 children with bacterial pneumonia （ the group A） , 60 children with mycoplasma pneumonia （ the group B） , 30 children with viral pneumonia （the group C） and 30 healthy children （the control group）. The differences were compared among the four groups. Results The levels of PCT, CRP and WBC counts were significantly higher in the groups A, B and C than in the control group （P〈0. 05）, which was the highest in the group A. The area under ROC curve was signif-icantly higher in CAP children than in CRP children （P〈0. 05）. Conclusion The PCT level has some clinical val-ue in the determination of pathogen-causing CAP in children, which can provide the reference for physicians to ration-ally use antibiotics in early stage.