期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

IL-21R、MMP-2在非小细胞肺癌中的表达及相关性研究 被引量：4

Correlation study of expression of IL-21 R and MMP-2 in patients with non-small cell lung cancer
下载PDF
导出
摘要 目的检测白介素-21受体(interleukin-21R,IL-21R)、基质金属蛋白酶-2(matrix metalloproteinases-2,MMP-2)在非小细胞肺癌(Non-small-cell lung cancer,NSCLC)癌组织中的表达,并探讨IL-21R、MMP-2的表达在NSCLC发生、发展及浸润转移的影响。方法采用免疫组化法检测50例NSCLC组织及20例正常肺组织对照组中IL-21R、MMP-2的表达,分析其阳性表达率与NSCLC患者临床病理特征的关系,并探讨其相关性。结果 NSCLC癌组织中IL-21R、MMP-2的阳性表达率均显著高于正常肺组织,且两者表达呈负相关(P<0.05);IL-21R和MMP-2的表达与淋巴结转移、临床分期及组织分化程度相关。结论 NSCLC中MMP-2的表达与其浸润转移正相关,其表达增加表示NSCLC有较高恶性生物学行为;IL-21R的表达与NSCLC浸润转移的呈负相关,且IL-21R、MMP-2在NSCLC发生及浸润过程中具有相关性。 Objective To investigate the expression of interleukin-21 receptor （IL-2R） and matrix metallo-proteinase-2 （MMP-2） in patients with non-small cell lung cancer （NSCLC）, and to discuss the influence of the ex-pression of IL-21R and MMP-2 to the disease. Methods The expression of IL-21R and MMP-2 was detected by im-munohistochemical method in 50 patients with non-small cell lung cancer and 20 people with normal lung tissue. The correlation of the positive expression rate of IL-21R and MMP-2 to pathological characteristics was analyzed. Results The positive rate of IL-2R and MMP-2 in NSCLC patients was significantly higher than in the control group, and they were negatively correlated （P〈0. 05）. The expression of IL-21R and MMP-2 was related to clinical stages, lymph node metastasis status and tissue differentiation degree. Conclusion The expression of MMP-2 in NSCLC pa-tients is positively related with metastasis, which the increased expression shows higher malignant biological behavior in NSCLC patients. The expression of IL-21 R shows a negative correlation with metastasis.
作者 戚胜波 于奇
机构地区 安徽医科大学解放军临床学院 解放军第
出处 《临床肺科杂志》 2014年第12期2232-2235,共4页 Journal of Clinical Pulmonary Medicine
关键词 白介素-21受体 基质金属蛋白酶-2 肺癌 肺恶性肿瘤 非小细胞肺癌 interleukin-21R lung cancer pulmonary malignant tumor non-small cell lung cancer
分类号 R734.2 [医药卫生—肿瘤]
  • 相关文献

参考文献11

  • 1Toh CK. The changing epidemiology of lung cancer. [ J ]. Methods Mol Biol. 2009 ;472:397 - 411.
  • 2Denman C J, Senyukov VV, Somanchi SS, et al. Membrane-bound IL-21 promotes sustained ex vivo proliferation of human natural kil- ler cells [ J]. PLoS One. 2012 ;7 ( 1 ) :e30264.
  • 3Willis AL, Sabeh F, Li XY, et al. Extracellular matrix determi- nants and the regulation of cancer cell invasion stratagems [ J ]. J Microsc. 2013 Sep;251 (3) :250 -60).
  • 4Kesselring R, Jauch D, Fichtner-Feigl S. Interleukin 21 impairs tumor immunosurveillanee of colitis-associated eoloreetal cancer [ J 1. Oncoimmunology. 2012 Jul 1 ; 1 (4) :537 - 538.
  • 5Sarosiek KA, Malumbres R, Nechushtan H, et al. Novel IL-21 signaling pathway up-regulates c-Myc and induces apoptosis of dif- fuse large B-cell lymphomas [ J ]. Blood. 2010 Jan 21 ; 115 (3) : 570 - 80.
  • 6Ma HL, Whitters MJ, Konz RF,et al. IL-21 activates both innate and adaptive immunity to generate potent antitumor responses that require perforin but are independent of IFN-gamma[ J]. J Immu- nol, 2003 Jul 15 ;171(2):608-615.
  • 7Zeng R, Spolski R, Finkelstein SE,et al. Synergy of IL-21 and IL-15 in regulating CD8 + T cell expansion and function [ J ]. J Exp Med. 2005 Jan 3 ;201 ( 1 ) :139 -48.
  • 8Caruso R, Fina D, Peluso I, et al. IL-21 is highly produced in Helicobacter pylori-infected gastric mucosa and promotes gelatinas- es synthesis[J]. J Immunol. 2007 May 1 ;178(9) :5957 -65.
  • 9孙玉满,刘宏侠,杨俊泉,汪宏斌,张玲,王宝良,郑斯祥,李荫堂.非小细胞肺癌中HIF-1α、MMP-2的表达及其相互关系探讨[J].临床肺科杂志,2013,18(10):1910-1911. 被引量：4
  • 10路会玲,王翎.NF-κB、MMP-2在非小细胞肺癌中的表达[J].临床肺科杂志,2011,16(11):1740-1742. 被引量：7

二级参考文献43

  • 1Rayet B,Gelinas C.Aberrant rel/nfkb genes and activity in human cancer[J].Oncogene,1999,18(49):6938-6947.
  • 2Mercurio F,Manning AM.NF-kappa B as a primary regulator of the stress response[J].Oncogene,1999,18(45):6163-6171.
  • 3JoH,ZhangR,Zhang H,et al.NF-kappa B is nequiredfor H-ras oncogene induced abnormal cell proliferation and tumorigenesis[J].Oncogene,2000,19(7):841-849.
  • 4Lamper K,Machein U,Machein M R,et al.Expression of matrix metalloproteinases and their tissue inhibitors in human brain tumors[J].Am Jpathol,1998,153:4292432.
  • 5Person S L,Watson S A,Brown P D,et al.Matrix metalloproteinases[J].BrJ Surg,1997,84:1602166.
  • 6Zeng ZS,Cohen A M,Guillem J G.Loss of basement membrane type V collagen is associated with increased expression of metallo protemases 2 and 9(MMP-2 and MMP-9) during human colorectal tumorigenesis[J].Carcingenesis,1999,20(5):749.
  • 7Still K,Robson C N,Autzen P,et al.Localization and quantification of mRNA for matrix metalloproteinases-2(MMP-2) and tissue inhibitor of matrix metalloproteinases (TIMP-2) in human benign and malignant prostatic tissue[J].Pmstate,2004,42(1):18-25.
  • 8Rangaswami H,Bulbule A,Kundu G C.Nuclear factor inducing kinase plays crucial role in osteopontin induced MAPK/IKK dependent nuclear factor kB-mediated promatrix metalloproteinase-9 activation[J].J Biol Chem,2004,279 (37):38921.
  • 9Philip S,Bulbule A,Kundu GC.Osteopontin stimulates tumor growth and activation of promatrix metalloproteinase-2 through nuclear factor-kappa B-mediated induction of membrance type 1 matrix metalloproteinase in murine melanom cell[J].J Biol Chem,2001,276(48):44926-44935.
  • 10Kom T, Bettelli E, Oukka M,et al. IL-17 and Thl7 Cells[ J ]. An- nu Rev immunol,2009 ,27 :485 -517.

共引文献12

同被引文献21

引证文献4

二级引证文献9

临床肺科杂志
2014年 第12期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部