脑心通联合阿托伐他汀对老年脑梗死患者颈动脉粥样硬化危险因素的影响

Effects of Nao Xin Tong Combined with Atorvastatin on Carotid Atherosclerosis Relative Factors in Elderly Cerebral Infarction Patients

目的:研究脑心通联合阿托伐他汀对老年脑梗死患者颈动脉粥样硬化危险因素的影响。方法:将80例脑梗死颈动脉粥样硬化患者按完全随机原则分为治疗组和对照组各40例,对照组在常规治疗的基础上加用阿托伐他汀治疗,治疗组在对照组的基础上加用脑心通胶囊。6个月为1个疗程,检测患者治疗前后血液中总胆固醇(TC)、血清甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)含量及颈动脉粥样硬化斑块面积的大小和颈动脉内膜中层厚度(IMT)。结果:两组患者治疗后血液TC、TG、LDL-C含量均较治疗前不同程度下降,HDL-C含量增加,IMT及动脉粥样硬化斑块面积显著减小。治疗组各项观察指标改善程度均优于对照组,差异有统计学意义(P<0.05)。结论:脑心通联合阿托伐他汀对老年脑梗死患者颈动脉粥样硬化危险因素有显著的改善作用。

Objective： To study the effects of Nao Xin Tong combined with atorvastatin on carotid atherosclerosis relative factors in elderly cerebral infarction patients. Methods： The 80 elderly cerebral infarction patients with carotid atherosclerosis were randomly divided into 2groups, 40 cases each. The control group was treated with conventional therapy and atorvastatin, while the treatment group received Naoxintong capsule on the basis of the control group, for 6 months. The total cholesterol （TC）, serum triglyceride（TG）, low-density lipoprotein cholesterol （LDL-C）, high density lipoprotein cholesterol （HDL-C） and the size of carotid atherosclerotic plaque and carotid intima-media thickness （IMT） were observed. Results： After treatment, the level of TC, TG, LDL-C decreased, HDL-C increased, while the IMT and the area of arotid atherosclerotic plaque significant- ly reduced. The improvement of these indexes in the treatment group were superior to the control group （P〈0.05）. Conclusion： Nao Xin Tong capsule combined with atorvastatin can significantly improve those risk factors of carotid atherosclerosis in elderly cerebral infarction patients.