深圳市原住居民女性生殖道HPV感染与宫颈癌相关性

HPV Infection of Female Reproductive Tract and Prevalence of Cervical Cancer in Shenzhen Original Residents

[目的]了解深圳市原住居民女性人群的生殖道高危型人乳头瘤病毒（HPV）感染现状、宫颈上皮内瘤样病变（CIN）和宫颈癌的现患率。[方法]2009年6月至2009年10月在深圳市龙岗区坑梓街道办事处辖区25~59岁、3年内未做过宫颈癌筛查的原住居民女性进行整群抽样,并以同一辖区外来移民女性为对照。所有接受筛查女性均行宫颈液基细胞学检查及第二代杂交捕获技术（hybrid captureⅡ,HC-Ⅱ）高危型HPV检测。HPV阳性和/或细胞学≥ASCUS的女性行阴道镜检查和活检。[结果]共有942名原住居民妇女和1183名外来移民女性参加了本次调查。原住居民与外来移民妇女HPV阳性率分别为16.9%和11.8%（P〈0.05）。原住居民妇女CIN现患率为9.7%,其中CINⅡ及以上病变现患率为6.3%,外来移民CIN现患率5.1%,其中CINⅡ及以上病变现患率为2.6%。原住居民妇女CIN和CINⅡ及以上病变现患率均明显高于外来移民（P〈0.001）,尤以30~39岁年龄组最为明显。[结论]30~39岁年龄组妇女HPV感染和CIN现患率均较高,应作为宫颈癌防治的重点监测对象。

[Purpose] To investigate the prevalence of HPV infection of female reproductive tract,cervical intraepithelial neoplasia（CIN） and cervical cancer in Shenzhen original residents. [Methods] From June 2009 to October 2009,the original women from Kengzi street,Longgang subdistrict,Shenzhen city with 25~59 years-old and without cervical cancer screening 3 years were selected by cluster sampling. The migrant women in the same area as the control. The ThinPrep cytology and the HC-Ⅱ HPV assay were processed. All women with ≥ASCUS and/or a positive HC-Ⅱ HPV test were asked to return for colposcopy.[Results] A total of 942 original women and1183 migrant women participated in the study. The HPV positive rate in original people and migrant women were 16.9% and 11.8% respectively（P0.05）. The prevalence of cervical intraepithelial neoplasia（CIN） and ≥CINⅡ in original women was 9.7%,6.3% respectively,and in migrant women was 5.1%,2.6% respectively. The prevalence of CIN and ≥CINⅡ in original women were significantly higher than that in migrant women（P0.001）,particularly in the 30 to 39 years groups.[Conclusion] The prevalence of HPV infection and CIN were both high in original women aged from 30 to 39,so this age group women should be focus on monitoring.