不规则抗体筛查及特异性鉴定结果分析

Results analysis of irregular antibodies screening and identification of the specificity

目的探讨红细胞血型不规则抗体的分布规律及其临床意义。方法应用微柱凝胶抗球蛋白检测技术对6 352例患者进行不规则抗体筛查、鉴定。结果在6 352例患者中检出红细胞同种不规则抗体阳性者62例(男27例,女35例),阳性率0.97%。有输血史和(或)妊娠史者54例,其中Rh血型系统不规则抗体43例(含抗-E抗体34例),MNSS系统7例,Lewis系统2例,Kidd系统2例,P系统2例,Diego系统1例,无特异性5例。Rh血型系统不规则抗体阳性患者均有输血史和(或)妊娠史。结论不规则抗体阳性患者中女性占多数,大多曾经有输血史和(或)妊娠史,以Rh血型系统抗体最为常见。

Objective To discuss the distribution of irregular antibodies of red blood cells and its clinical significance.MethodsMicro-column gel anti-globulin technique was used to screen and identify the irregular antibodies in 6 352 patients.Results In 6 352 patients,there were 62 cases（27 males,35 females）having positive results in irregular antibody detection,and the positive rate was 0.97%.There were 54 cases having transfusion history and/or pregnancy history,including 43 cases of irregular antibodies of Rh system（containing 34 cases of anti-E antibody）,7 cases of MNSS system,2 cases of Lewis system,2 cases of Kidd system,2 cases of P system,1 cases of Diego system,and 5 cases with non-specificity.All of the patients whose irregular antibodies of Rh blood group system were positive had transfusion history and/or pregnancy history.Conclusion Most of the patients with irregular antibody positive are females,who mostly have transfusion history and/or pregnancy history,and the irregular antibodies of Rh system are the most common.