降钙素原联合C反应蛋白检测对早期血流感染的诊断价值

Diagnostic value of C-reactive protein combined with procalcitonin in the early detection of blood stream infection

目的探讨降钙素原(PCT)联合C反应蛋白(CRP)检测早期诊断血流感染的价值。方法选择109例血流感染患者为研究组,109例其他局部感染患者为对照组,检测两组血清PCT、CRP水平,并进行血培养与菌种鉴定,评价PCT联合CRP检测的诊断效能。结果研究组血清PCT、CRP水平和检测阳性率显著高于对照组(P<0.05)。在血流感染患者中,革兰阴性菌感染患者血清PCT水平显著高于革兰阳性菌感染患者(P<0.05)。以0.35ng/mL和10mg/L分别作为PCT和CRP的cut-off值时,二者联合诊断血流感染的ROC曲线下面积最大(0.81)。结论 PCT联合CRP检测对血流感染的早期诊断价值较高,必要时可调低PCT的判断水平,从而提升诊断效能。

Objective To investigate diagnostic the value of the procalcitonin（PCT）combined with C-reactive protein（CRP）in the early detection of bloodstream infection.Methods 109 patients with bloodstream infection were collected for the study group.109 patients with other local infection were matched as the control group.Serum PCT,CRP levels,blood culture and strain identification were detected of all subjects.Early diagnostic value of PCT united CRP for bloodstream infection was evaluated.ResultsThe serum PCT,CRP levels and positive rate was significantly higher in study group（P〈0.05.The serum PCT levels in patients with Gram-negative bacterial infections was significantly higher than the Grand-positive bacteria ones.The area under the ROC curve of bloodstream infection was largest（0.81）as the cut-off value PCT=0.35ng/mL and CRP=10mg/L.Conclusion Procalcitonin combined with C-reactive protein has better diagnostic value in the early bloodstream infection,which could enhance the diagnostic performance with reduction of the PCT diagnostic level if necessary.