柴胡疏肝散加味联合黛力新治疗肝郁气滞型功能性消化不良的临床研究

Clinical Study of Modified Chaihu Shugan Powder Combined with Deanxit in Treatment of Liver Qi Stagnation Type of Functional Dyspepsia

目的:探讨柴胡疏肝散加味联合黛力新治疗肝郁气滞型功能性消化不良的疗效。方法:功能性消化不良患者120例按随机数字表法分为观察组和对照组,每组60例。对照组给予常规疗法和黛力新,观察组加用柴胡疏肝散加味。比较两组治疗前后症状积分、HAMD评分和HAMA评分,不良反应及复发率。结果:观察组总有效率为95.0%(57/60),对照组为80.0%(48/60),差异有统计学意义(χ2=5.79,P<0.05)。观察组治疗2周时症状积分即较治疗前显著下降(t=6.65,P<0.05),对照组在治疗4周时较治疗前有明显差异(t=6.91,P<0.05),观察组治疗2、4周时症状积分均显著低于对照组(t=4.11、4.53,P<0.05)。两组患者治疗后HAMD评分和HAMA评分均较治疗前显著降低(t=8.65、9.62、7.91、5.11,P<0.05),治疗后观察组HAMD评分和HAMA评分均显著低于对照组(t=4.13、4.02,P<0.05)。观察组不良反应发生率为6.7%(4/60),对照组为5.00%(3/60),差异无统计学意义(χ2=0.56,P>0.05)。观察组复发率为2.6%(1/38),对照组为22.7%(6/22),差异有统计学意义(χ2=4.72,P<0.05)。结论:柴胡疏肝散加味联合黛力新治疗肝郁气滞型功能性消化不良能改善焦虑和抑郁情绪,促进症状迅速缓解,降低复发率,且不良反应少,值得临床推广应用。

Objective： To investigate the Modified Chaihu Shugan Powder combined with Deanxit on the treatment of liver qi stagnation type of functional dyspepsia. Methods ： 120 case of functional dyspepsia patients were randomly divided into observation group and control group with 60 cases in each group. The control group was given conventional therapy and deanxit and the observation group added Modified Chaihu Shugan Powder. Symptom score, HAMD score and HAMA score, adverse reactions and recurrence rate before and after treatment of two groups were compared. Results ： The total effective rate of observation group was 95% （57/60） and that of the control group was 80% （48/60）. The difference was statistically significant （ X2 = 5.79 ,P 〈 0.05 ）. The symptom score of observation group was significantly decreased after 2 weeks treatment and was lower than that before treatment （ t = 6.65, P 〈 0.05 ）. The symptom score of control group was significandy different at 4 weeks treatment than that before treatment （t = 6.91 ,P 〈 0.05 ）. The symptom score of observation group at 2,4 weeks were significantly lower than that in the control group （ t = 4.11,4.53, P 〈 0.05 ）. The HAMD score and HAMA score of two groups decreased significantly at the end of treatment （ t = 8.65,9.62,7.91,5.11, P 〈 0. 05 ） after treatment. The HAMD score and HAMA score in observation group were significantly lower than those in the control group （ t = 4.13,4.02, P 〈 0.05 ）. The incidence of adverse reaction of observation group was 6.7% （4/60） and that of the control group was 5% （3/60） and there was no significant difference （x2 =0.56,P 〉0. 05）. The recurrence rate of observation group was 2.6% （1/38） and that in the control group was 22.7% （6/22）. The difference was statistically significant （ x2 = 4.72, P 〈 0. 05 ）. Conclusion ： Modified Chaihu Shugan Powder combined with Deanxit on the treatment of liver qi stagnation type of functional dyspepsia can improve the anxiety and depression of patients, promote alleviate the symptoms quickly,reduce the recurrence rate and with less adverse reaction. It is worthy of clinical application.