去甲斑蝥素主动肝靶向性药物设计研究进展

Research progress on active liver-targeting drug design of norcantharidin

去甲斑蝥素是临床常用抗肝癌药物,抗肿瘤作用强,并且具有保护肝细胞、提高免疫功能等作用。为提高其对肝脏的靶向性,降低对其他脏器的毒性,近年来不断有学者进行去甲斑蝥素主动肝靶向性药物的设计,如单克隆抗体导向药物、去唾液酸糖蛋白介导的药物等。本文综述了近十年来对去甲斑蝥素主动肝靶向性药物的研究进展,为开发应用于临床的去甲斑蝥素主动肝靶向性药物的研究提供参考。

Norcantharidin is a commonly used anti-liver cancer drug with high anti-tumor activity in clinical practice. It can protect liver cells and improve immune functions as well. In recent years, research-ers have been focusing on designing active liver-targeting drugs of norcantharidin, such as monoclonal anti-body-directed drug or asialoglycoprotein receptor-mediated drug, to improve its specificity to liver as well as to reduce its toxicity to other tissues and organs. This paper reviews the research progress on active liver-tar-geting drugs of norcantharidin derivertives in recent ten years. All of these researches aim to will provide ref-erences to further study and exploitation on clinically available norcantharidin active liver-targeting drugs.