小剂量安体舒通对社区单纯收缩期高血压患者血压影响的临床研究

Effects of small dose of spironolactone on the patients with isolated systolic hypertension in community

目的:研究小剂量安体舒通对单纯收缩期高血压(isolated systolic hypertension,ISH)患者血压的影响。方法:83例ISH患者随机分为治疗组和对照组,在继续目前降压治疗的基础上,治疗组患者每天服用安体舒通10 mg,对照组患者每天服用维生素C 0.3 g,比较治疗前和治疗13周后两组患者的血压和电解质、血肌酐水平。结果:与治疗前相比,治疗组患者的收缩压明显降低,而舒张压和血钾水平没有明显变化,对照组的收缩压、舒张压以及血钾和血肌酐水平没有明显变化。结论 :小剂量的安体舒通可以安全有效地降低ISH患者的收缩压。

Objective： To study the effect of small dose of spironolactone on the patients with isolated systolic hypertension （ISH） in community. Methods： Eighty-three cases of ISH patients were randomly divided into a treatment group and a control group. Based on the original antihypertensive treatment, patients in the treatment group took spironolactone at a dose of 10 mg daily while vitamin C 0.3 g daily in the control group. Blood pressure, electrolytes and serum creatinine levels in all patients were detected before treatment and 13 weeks after treatment. Results： Systolic blood pressure （SBP） was significantly reduced, and diastolic blood pressure （DBP） and serum potassium levels had no significant change in the treatment group 13 weeks after treatment while SBP, DBP, serum potassium levels and serum creatinine levels had no significant change in the control group. Conclusion： The SBP of patients with ISH can be safely and effectively reduced by taking a small dose of spironolactone.