促分泌剂治疗慢性便秘的研究进展

Research progress of secretagogue agents for chronic constipation

便秘是一种常见的胃肠道症状,困扰着全球近三分之一的人群,胃肠道功能性疾病所引起的慢性便秘尚无特异性的治疗方法,传统的通便药物往往不能使患者满意。促分泌剂是一类以氯离子通道为靶点,作用机制明确的新型药物。笔者通过整理近年来促分泌剂治疗慢性便秘的国内外研究进展,从分子机制、临床试验等方面,综述促分泌剂治疗慢性便秘的特点、优势等,以期为通便药物的研发提供思路。

Chronic constipation is a common symptom of gastrointestinal tract, which bothers almost one third of global population. More seriously, the chronic constipation caused by functional gastrointestinal diseases has no specific treatment, and traditional drugs are always unsatisfactory. Secretagogue agents are a kind of novel drugs targeting chloride channel with clear mechanism, The aim of this article is to review related research progress in this area, mainly focusing on molecule mechanism and clinical trials. Eventually, their merits and traits for the long-term development of laxatives are discussed.