手足口病重症病例病毒分型与临床特点分析

The Virus types and clinical features in severe cases of hand-foot-mouth disease

目的分析手足口病重症病例的病毒分型与临床特点。方法收集济宁市第一人民医院2013年3月-2014年3月诊治的手足口病重症患者52例，分析其病毒分型和临床特点。结果36名患者为EV71阳性，占总数的69．23％。有1名患者死亡，病死率为1．92％。所有患者均有发热、皮疹症状，有80．77％（42例）病例出现肢体抖动或无力，44．23％（23例）患者出现呕吐症状，80．77％（42例）患者白细胞（WBC）水平超过15×10^9/L。结论导致手足口病重症病例的病原体主要是EV71，患者多出现发热、肢体抖动或无力，白细胞水平升高。

Objective To investigate the virus types and clinical characteristics in severe cases of hand-foot-mouth disease. Methods A retrospective analysis was earried out in the First People＇s Hospital of Jining from March 2013 to March 2014. Fifty-two severe cases of hand-foot-mouth disease were included in the study. The virus types and clinical characteristics were studied. Results The results showed that 36 ea- ses （80. 77%） were positive for EVT1. One patient died, and the mortality rate was 1.92%. All patients showed symptoms of fever and skin rash. Forty-two cases （ 80. 77% ） showed limb jitter or weakness. Twen- ty-two cases （44. 23 % ） had vomiting. Forty-two cases （80. 77%） showed high white blood cell （WBC） lev- el （ 〉 15 × 10^9/L）. Conclusions The main pathogen in severe cases of hand-foot-mouth disease was EV71, the clinical manifestations were mainly fever, limb shaking or weakness, and elevated white blood cell level.