黄芪注射液联合曲美他嗪治疗急性病毒性心肌炎的临床疗效观察

Clinical observation of astragalus injection combined with trimetazidine for the treatment of acute vi- ral myocarditis

目的探讨黄芪注射液与曲美他嗪联合治疗急性病毒性心肌炎（AVM）的临床疗效。方法102例AVM患者随机分为观察组与对照组，各51例。对照组予以常规综合治疗，观察组在对照组的基础上加用黄芪注射液和曲美他嗪，比较两组的疗效。结果观察组的临床总有效率为96．08％，显著高于对照组的78．43％（P〈0．05）；观察组的心电图总有效率为92．16％，显著高于对照组70．59％（P〈0．05）；观察组治疗后中医证候评分显著低于对照组（P〈0．05）；观察组治疗后CK．MB、cTnI、cTnT以及BNP水平均较治疗前显著降低，且显著低于对照组（P〈0．05）；观察组的不良反应率为5．88％，与对照组的3．92％比较无明显差异（P〉0．05）。结论黄芪注射液联合曲美他嗪治疗AVM可有效改善患者的心功能以及心肌酶谱，疗效显著且不良反应较少，值得推广应用。

Objective To investigate the clinical efficacy of astragalus injection combined with trim- etazidine for the treatment of acute viral myocarditis （AVM）. Methods 102 patients with AVM were ran- domly divided into observation group and control group, 51 cases in each group. The control group received conventional comprehensive treatment, the observation group received astragalus injection and trimetazidine treatment on the basis of the control group, the efficacy of the two groups were compared. Results The total clinical efficiency of observation group was 96. 08%, significantly higher than 78.43% of the control group （P 〈0. 05）. The total effective rate of ECG of observation group was 92. 16%, significantly higher than 70. 59% of the control group （P 〈 0.05 ）. The traditional Chinese medicine（TCM） syndrome score of the observation group after treatment was significantly lower than the control group （ P 〈 0.05）. The CK-MB, cTnI, cTnT and BNP levels of observation group after treatment were significantly lower than those of the be- fore treatment, and these indices were significantly lower than the control group （P 〈 0. 05）. The rate of ad-verse reactions of observation group was 5.88% and had no significant difference with 3.92% in the control group （ P 〉 0. 05）. Conclusions Astragalus injection combined with trimetazidine for the treatment of AVM can improve the cardiac function and myocardial enzymes of patients, which has a significant effect and fewer adverse reactions, should be widely applied.