胱抑素C对颈动脉病变的影响及诊断价值

Impact and diagnostic capability of cystatin C in carotid artery lesion

目的:探讨胱抑素C对颈动脉病变的影响及其在颈动脉病变中的诊断价值,为预防动脉粥样硬化提供依据。方法:从某医院体检中心选择颈动脉病变者223例为病例组,正常组285例。运用Logistic回归筛选颈动脉病变的主要危险因素,并运用ROC曲线分析胱抑素C及其组成的综合协变量对颈动脉病变的诊断价值。结果:胱抑素C是颈动脉病变的主要危险因素之一(OR=2.70,P<0.001)。在单协变量比较中胱抑素C对颈动脉病变的诊断价值最高(AUC=0.77,P<0.001),当其在1.08 mg/L时,其诊断的灵敏度和特异度最高,分别为74.9%和71.4%;在颈动脉病变的诊断中综合协变量与胱抑素C相比具有更高的诊断价值,其灵敏度和特异度分别为78.5%和75.8%。结论:血清胱抑素C是颈动脉病变的危险因素,其对诊断颈动脉病变具有较高的灵敏度和特异度;综合协变量对颈动脉病变的诊断价值更高。

Objective：To investigate the impact of cystatin C level on carotid artery lesion and the diagnostic value of this marker in carotid condition for evidence of carotid atherosclerosis prevention.Methods：223 with carotid artery lesion （lesion group） and 285 without carotid artery lesion（control group） were included from the Physical Examination Center of a hospital .Logistic regression analysis was performed to estimate the major risk factors for carotid ar-tery lesion,and the diagnostic value was verified on cystatin C and its integrated covariate basis by receiver operating characteristic （ ROC） curve.Results：Blood level of cystatin C was one of the substantial risk factors for carotid artery lesion（OR=2.70,P〈0.001）.By comparison of the single concomitant variables,cystatin C level was most valuable in estimation of the degree of carotid artery lesion（AUC=0.77,P〈0.001）,and the sensitivity（74.9%） and specificity（71.4%） were the highest when the level of cystatin C arrived at 1.08 mg/L.Nevertheless,the sensitivity and specificity would be 78.5% and 75.8%,respectively,if taken the integrated covariates with cystatin C level into consideration.Conclusion：Cystatin C is a risk factor for carotid artery le-sion,and has higher sensitivity and specificity in diagnosis of the carotid condition,in which integrated covariates can be most valuable.