甲泼尼松龙琥珀酸钠致血糖升高1例

One Case of Elevated Blood Glucose Induced by Methylprednisolone Sodium Succinate

1例慢性支气管炎急性发作合并阻塞性肺气肿80岁男性患者,给予注射用甲泼尼松龙琥珀酸钠抗炎对症处理,连续使用5天,空腹血糖由2.62 mmol/L升至5.0 mmol/L,考虑为注射用甲泼尼松龙琥珀酸钠引起,给予停药处理。第7天,因气喘加重给予甲泼尼松龙琥珀酸钠。第11天,患者血糖6.2 mmol/L,遂给予阿卡波糖降糖处理。第12天,患者空腹血糖上升至6.8 mmol/L,将注射用甲泼尼松龙琥珀酸钠更换为波尼松口服。继续治疗3天,复查血糖3.2 mmol/L。

An eighty-year-old male patient with acute attack of chronic bronchitis combined with obstructive pulmonary emphysema received methylprednisolone sodium succinate for injection . After five days of treatment , his fasting blood glucose （FBG） increased from 2.62 mmol/L to 5.0 mmol/L, then methylprednisolone sodium succinate was withdrawn . On day 7 after stopping use of the medicine , methylprednisolone sodium succinate was readministered because of his asthma aggravation. On day 11, FBG rose to 6.2 mmol/L, then he was given acarbose for hypoglycemic treatment. On day 12, his FBG continued to increase to 6.8mmol/L, then he received oral prednisone instead of methylprednisolone sodium succinate . After 3 days of treatment , his FBG lowered to 3 . 2 mmol/L .