腹型肥胖对糖尿病人群新发高尿酸血症影响的研究

The relationship between abdominal obesity and new-onset hyperuricemia in diabetic population

目的 探讨糖尿病患者腹型肥胖与新发高尿酸血症（HUA）发病风险间的关系. 方法 本研究采用前瞻性队列研究,以参加2006～2007年度开滦集团职工健康体检的糖尿病患者,且既往无HUA病史及相关资料完整者5122例作为观察队列.依据基线WC将观察对象分为肥胖组与非肥胖组,比较两组2010～2011年度健康体检时新发HUA的发病率,并采用多因素Logistic回归分析肥胖与新发HUA发病风险间的关系. 结果 （1）观察队列的平均随访时间为（48.9±5.6）月,HUA发病率为5.6％（285/5122）.肥胖组HUA发病率高于非肥胖组（6.9％ vs3.8％,P＜0.01）;（2）多因素Logistic回归分析显示,肥胖、性别、SBP、基线血清尿酸（SUA）水平是新发HUA的影响因素,其中肥胖是独立危险因素（OR=1.44,95％CI：1.09～1.89）. 结论 腹型肥胖可能是糖尿病患者新发HUA的独立危险因素.

Objective To explore the relationship between abdominal obesity and new-onset hyperuricemia in diabetic population.Methods A total of 5122 diabetic patients without history of hyperuricemia who had participated in the health examination between 2006 and 2007 were selected as the observation cohort in this prospective cohort study.The observation population was divided into obesity group and non-obesity group according to their waist circumference.The incidence of new-onset hyperuricemia in the health examination from 2010 to 2011 was compared between obesity and non-obsity groups.The relationship between abdominal obesity and new-onset hyperuricemia was analyzed by multiple logistic regression analysis.Results （1）The average follow-up time of subjects was （48.9± 5.6） months.The incidence rate of hyperuricemia was 5.6% （285/5122）.The incidence rate of HUA was higher in obesity group than in non-obesity group （6.9 % vs 3.8 %,P 〈 0.01） ; （2） Multiple logistic regression analysis showed that abdominal obesity,sex,SBP,the baseline uric acid were the effective factors for new-onset hyperuricemia,and the obesity was independent risk factors （OR =1.44,95 % CI：1.09 ～ 1.89）.Conclusion Abdominal obesity may be an independent risk factor for the new-onset hyperuricemia in diabetic patients.