柏子养心方合疏肝宁神散治疗广泛性焦虑障碍

Clinical Study of Baizi Yangxin Decoction Combined with Shugan Ningshen Powder in Treating Patients with Generalized Anxiety Disorder

目的:探讨柏子养心方合疏肝宁神散治疗广泛性焦虑障碍临床效果。方法:收治广泛性焦虑障碍患者120例,采用随机数字表法分为对照组(60例)和中医方剂组(60例);其中对照组患者采用草酸艾司西酞普兰治疗;中医方剂组患者则柏子养心方合疏肝宁神散治疗;比较两组患者临床疗效,治疗前后焦虑自评量表(SAS)评分、汉密尔顿焦虑量表(HAMA)评分、中文版健康调查简易量表(SF-36)评分及随访复发率等。结果:对照组与中医方剂组患者治疗总有效率分别为70.00%,95.00%,中医方剂组患者临床疗效显著优于对照组,差异有统计学意义(P<0.05);两组患者治疗后SAS评分、HAMA评分及SF-36评分较治疗前显著改善,且中医方剂组患者治疗后评分优于对照组,差异有统计学意义(P<0.05);同时中医方剂组患者随访复发率6.67%显著低于对照组38.33%,差异有统计学意义(P<0.05)。结论:柏子养心方合疏肝宁神散治疗广泛性焦虑障碍可有效改善焦虑症状,改善生活质量,并降低复发风险,疗效优于西药。

Objective： To investigate the clinical effects of Baizi Yangxin decoction combined with Shugan Ningshen powder in the treatment of generalized anxiety disorder. Method： One hundred and twenty patients with generalized anxiety disorder were chosen and randomly divided into the control group（ 60 patients）and trational Chiese medicine（ TCM） prescription group（ 60 patients）. Patients in control group received escitalopram oxalate and patients in TCM prescription group received Baizi Yangxin decoction and Shugan Ningshen powder. The clinical efficacy,self-rating anxiety scale（ SAS） score,hamilton anxiety scale（ HAMA） score,simple health survey scale（ SF-36） score and recurrence rate between two groups were compared before and after treatment. Result： The clinical efficacy of TCM prescription group were better than control group with statistically significant differences（ P〈0.05）. The SAS score,HAMA score and SF-36 score after treatment of both groups were better than before with statistically significant differences（ P〈0.05）. Besides,the effect of TCM prescription group were better than control group,with statistically significant differences（ P〈0.05）. The recurrence rate of TCM prescription group were lower than control group with statistically significant（ P〈0.05）. Conclusion：Compared with western medicine,using Baizi Yangxin decoction combined with Shugan Ningshen powder could efficiently improve the anxiety symptoms and the quality of life,and reduce the risk of recurrence in the treatment of generalized anxiety disorder.