半夏泻心汤加味配伍吗丁啉辅助治疗功能性消化不良

Clinical Observation on Effect of Banxia Xiexin Decoction Combined with Domperidone in Treating Patients with Functional Dyspepsia

目的:研究半夏泻心汤加味配伍吗丁琳辅助治疗功能性消化不良的临床疗效。方法:将80例功能性消化不良患者随机分为两组,对照组给予吗丁啉治疗,观察组给予半夏泻心汤加味配伍吗丁琳辅助治疗,比较两组患者治疗效果、临床症状、血浆胃动素水平、心理状态。结果:观察组治疗总有效率(90%)明显高于对照组(80%)(P<0.05);观察组患者的腹痛、腹胀、反酸、嗳气的评分分别为(0.72±0.06),(1.64±0.08),(0.62±0.08),(0.95±0.04)分,明显低于对照组(P<0.05);观察组血浆胃动素(398.68±120.14)μg·L-1明显高于对照组(P<0.05);观察组患者的躯体化评分、强迫症状评分、人际敏感评分、抑郁症状评分、焦虑症状评分、敌对症状评分、恐怖症状评分、偏执症状评分、精神症状评分均明显低于对照组(P<0.05)。结论:半夏泻心汤加味配伍吗丁琳辅助治疗有助于改善临床症状、促进血浆胃动素高表达、缓解负面情绪,提高治疗效果。

Objective： To study the effect of auxiliary treatment of Banxia Xiexin decoction combined with domperidone in treating functional dyspepsia. Method： Eighty patients with functional dyspepsia were enrolled and divided into observation group and control group. Patients in observation group received auxiliary treatment of Banxia Xiexin decoction combined with domperidone. Patients in control group received domperidone alone. Then the therapeutic effect,clinical symptoms,plasma motilin level and psychological state between two groups were compared. Result： The total effective rate in observation group（ 90%） was significantly higher than that in control group（ P〈0.05）. The abdominal pain,abdominal distention,acid regurgitation,belching scores in observation group were（ 0. 72 ± 0. 06）,（ 1. 64 ± 0. 08）,（ 0. 62 ± 0. 08） and（ 0. 95 ± 0. 04） respectively,which were lower than control group（ P〈0.05）. The plasma motilin of（ 398. 68 ± 120. 14） μg ·L- 1in observation group was significantly higher than control group（ P〈0.05）. The somatization score,obsessivecompulsive symptoms score,interpersonal sensitivity score,depression symptom scores,anxiety symptoms score,hostile score,terror symptom score,paranoid symptoms score in observation group were significantly lower than those in control group（ P〈0.05）. Conclusion： Using Banxia Xiexin decoction combined with domperidone is helpful to improving clinical symptoms,promoting level high expression of plasma motilin,alleviating negative emotions and improving effect of treatment.