银僵汤对组织细胞增生性坏死性淋巴结炎患者TNF-α、CD4^+、CD4^+/CD8^+的影响

Effect of Yinjiang Decoction on TNF-α、CD4^+、CD4^+/CD8^+ of Histiocytic Necrotic Lymphadenitis

目的:观察银僵汤对组织细胞增生性坏死性淋巴结炎患者TNF-α、CD4+、CD4+/CD8+的影响。方法:将87例组织细胞坏死性淋巴结炎患者随机分为两组,治疗组以银僵汤口服,对照组以泼尼松口服,12 d为1个疗程,疗程结束后观察两组治疗前后TNF-α、CD4+、CD4+/CD8+的变化。结果:治疗组治疗后CD4+、CD4+/CD8+明显增高,与治疗前比较有显著性差异(P<0.01);两组治疗后相比,治疗组较对照组CD4+,CD4+/CD8+显著增高(P<0.05)。两组(组内)治疗前后TNF-α比较均有显著性差异(P<0.05)。结论:银僵汤治疗组织细胞增生性坏死性淋巴结炎作用机制可能与降低炎性因子(TNF-α),调节免疫水平(CD4+、CD4+/CD8+)相关。

Objective：To observe the therapeutic of Yinjiang decoction on TNF-α,CD4^＋,CD4^＋/CD8^＋ of histiocytic necrotic lymphadenitis（HNL）. Methods：Total 87 HNL patients were radomly divided into two groups. The treatment group was treated with Yinjiang decoction and the control group was treated with Prednisone. One treatment course is 12 days. The indexes of TNF-α,CD4＋,CD4＋/CD8＋ of the two groups were compared after one course. Results：The CD4^＋,CD4^＋/CD8^＋ of treatment group increased,compared with those before treatment and those of control group,there are significant differences（P〈0.01,P〈0.05）. Compared with before treatment,TNF-α of the two groups were significantly different（P〈0.05）. Conclusion：Using the Yinjiang decoction to treat HNL has a good curative effect. Its mechanism may be related to the function of reduing TNF-α and regulating the immunity levels.