孕期服用抑酸药与后代发生儿童哮喘关系的Meta分析

A meta-analysis of relationship between acid-suppressive drugs ingested by pregnant women and their descendent asthma

目的评估孕期服用抑酸药与后代发生儿童哮喘的关系。方法检索中国学术期刊全文数据库、美国MEDLINE数据库和荷兰EMBASE数据库,根据纳入标准筛选出国外的5篇文章,运用Review Manager 5.2分析软件,根据其异质性的不同,对这5篇有关孕期服用抑酸药与后代发生儿童哮喘关系的病例对照研究分别进行固定样本模型和随机效应模型的Meta分析。结果孕期服用抑酸药与后代发生儿童哮喘的关联明显（P=0.0004）,合并OR值为1.38,OR95%CI为1.15-1.65。结论孕期服用抑酸药与后代发生儿童哮喘有关。

Objective To explore the relationship between acid-suppressive drugs ingested by pregnant women and their descendent asthma.Methods We searched CNKI,MEDLINE,EMBASE databases,and according to the inclusion criteria,5 articles abroad were selected.The results of 5 case-control studies about the relationship between acid-suppressive drugs ingested by pregnant women and their descendent asthma were analyzed by Review Manager 5.2.Fixed sample model and random effect model of meta-analysis method was used.Results The occurrence of childhood asthma was positively correlated with acid-suppressive drugs consumption by their mother during pregnancy（ P= 0.0004）.The pools OR value was 1.38 and the OR value 95% CI was 1.15 - 1.65.Conclusion Acid-suppressive drugs consumption during pregnancy is an important risk factor of childhood asthma.