摘要
目的探讨抗菌药产生不良反应(ADR)的危险因素。方法采用1:2配对病例对照研究,回顾性收集病例组和对照组临床资料,用多因素条件logistic回归筛选危险因素。结果采用静脉滴注(OR=1.326,95%CI:1.145-1.892)、有药物过敏史(OR=3.314,95%CI:2.683-3.812)、联合用抗菌药(OR=2.734,95%CI:1.925-3.108)、喹诺酮药(相对于青霉素类药OR=1.399,95%CI:1.004-1.527)更易引发ADR。结论有药物过敏史、静脉滴注、联合用药、喹诺酮类药是抗菌药引发ADR的危险因素。
Objective To analyze the risk factors of adverse drug reactions (ADR) of antibacterial drug. Method The clinic data of case group and control group were collected respectively to screen the risk factors by using multiple logistic regression in condition in 1:2 matched case-control study. Results Using intravenous drip (OR=1.326, 95%CI: 1.145-1.892), drug allergy history (OR=3.314, 95%CI:2.683-3.812), using more than one type of antibacterial drug (OR=2.734, 95%CI:1.925-3.108), quinolone drugs (relative to penicilin drugs OR=1.399, 95%CI: 1.004-1.527) were easier to cause ADR. Conclusions Drug allergy history, using intravenous drip and more than one type of adverse drug, quinolone drugs were the risk factors relative to ADR causing by antibacterial drug.
出处
《国外医药(抗生素分册)》
CAS
2014年第6期255-257,共3页
World Notes on Antibiotics