布地奈德、沙丁胺醇联合异丙托溴铵雾化吸入在慢性阻塞性肺疾病急性加重期中应用的临床观察

Clinical Observation of Aerosol Inhalation of Budesonide and Ventolin Combined with Ipratropium Bromide for Acute Exacerbation of COPD

目的:观察布地奈德、沙丁胺醇联合异丙托溴铵雾化吸入在慢性阻塞性肺疾病急性加重期(AECOPD)中应用的临床疗效和安全性。方法:将64例AECOPD患者随机均分为研究组和对照组。对照组患者给予2 ml布地奈德和1 ml沙丁胺醇雾化吸入治疗,研究组患者在此基础上加入2 ml异丙托溴铵雾化吸入治疗。两组患者均每日2次给药,疗程均为7 d。对比两组患者治疗前后的肺功能指标和血气指标变化,观察临床疗效和不良反应情况。结果:治疗前两组患者的肺功能指标和血气指标比较,差异均无统计学意义(P>0.05);治疗后两组患者的肺功能指标和血气指标均较治疗前显著改善,且研究组患者均显著优于对照组,组内及组间比较差异均有统计学意义(P<0.01)。研究组患者治疗总有效率显著高于对照组(P<0.05)。两组患者均未出现严重不良反应,不良反应发生率比较差异无统计学意义(P>0.05)。结论:布地奈德、沙丁胺醇联合异丙托溴铵雾化吸入治疗AECOPD较未加用异丙托溴铵的疗效更显著,安全性相似。

OBJECTIVE：To observe the clinical efficacy and safety of aerosol inhalation of budesonide and ventolin combined with ipratropium bromide for acute exacerbation of COPD（AECOPD）. METHODS：A total of 64 patients with AECOPD were randomly divided into control group and study group. Control group was treated with aerosol inhalation of budesonide 2 ml and ventolin 1ml twice a day. Study group was additionally treated with aerosol inhalation of ipratropium bromide 2 ml twice a day on the basis of control group. Treatment course of 2 groups lasted for 7 d. The lung function and blood gas index of 2 groups were compared before and after treatment,and clinical efficacy and ADR were observed in 2 groups. RESULTS：There was no statistical significance in lung function index and blood gas index between 2 groups before treatment（P〉0.05）. Compared with before treatment,lung function index and blood gas index of 2 groups were improved significantly after treatment;the study group was significantly better than the control group;there was statistical significance（P〈0.01）. The total effective rate of study group was higher than that of control group significantly（P〈0.05）. No severe ADR was found in 2 groups,and there was no significant difference in the incidence of ADR（P〉0.05）. CONCLUSIONS：The aerosol inhalation of budesonide and ventolin combined with ipratropium bromide is more effective than budesonide and ventolin in the treatment of AECOPD,but have similar safety.