腹腔镜手术联合米非司酮治疗子宫内膜异位症临床效果观察

Clinical effect of laparoscopic surgery combined with mifepristone in treatment of endometriosis

目的探讨腹腔镜联合米非司酮治疗子宫内膜异位症的临床疗效及安全性。方法收集2011年1月—2014年3月商丘市妇幼保健院收治的子宫内膜异位症患者108例,根据腹腔镜术后是否联合药物治疗随机分为观察组57例和对照组51例,观察组患者给予腹腔镜联合米非司酮治疗,对照组患者仅给予腹腔镜手术治疗,比较两组治疗后的疗效、安全性及两组患者排卵恢复时间、月经恢复时间及妊娠情况。结果观察组患者治疗总有效率为91.23%,复发率为3.51%,明显优于对照组的82.35%和15.69%,差异有统计学意义(P<0.05)。观察组患者停药后排卵恢复时间、月经恢复时间及2年内妊娠情况均优于对照组,差异有统计学意义(P<0.05)。结论腹腔镜联合米非司酮治疗子宫内膜异位症临床疗效确切,提高患者的妊娠率,且复发率低,安全性好。

Objective To investigate the clinical efficacy and safety of laparoscopic mifepristone in treatment of endometriosis. Methods From January 2011 - March 2014 108 patients were admitted Shangqiu City, MCH endometriosis, whether combined drug treatment were randomly divided into observation group 57 cases and 51 cases in the control group according to laparoscopic surgery observation group were treated with laparoscopy combined with mifepristone treatment, patients in the control group only received laparoscopic surgery, two groups were compared after treatment efficacy, safety, and two groups of patients recovery time of ovulation, menstruation and pregnancy recovery time. Results The patients in the observation group, the total effective rate was 91.23 %, the recurrence rate was 3.51%, significantly better than 82. 35% and 15.69% in the control group, the difference was statistically significant （P 〈 0. 05 ）. After the observation group were stopping ovulation recovery time, recovery time of menstruation and pregnancy two years than the control group, the difference was statistically significant （ P 〈 0. 05 ）. Conclusion Laparoscopic mifepristone in treatment of endometriosis can, improve the patient＇s pregnancy, has recurrence rate and good security.