糖皮质激素治疗对哮喘患者胰岛素及其受体表达的影响

Effect of glucocorticoid treatment on insulin receptor expression in patients with asthma

目的分析糖皮质激素治疗对哮喘患者胰岛素及其受体的表达的影响。方法选取南阳市第一人民医院收治的支气管哮喘患者30例,设为观察组,给予患者连续1个月糖皮质激素治疗,测定治疗前后患者空腹血糖含量和血清内胰岛素含量,并采用酶联免疫吸附法对患者血清内可溶性胰岛素受体含量进行测定,并与同期收治的健康体检者(对照组)进行对比。结果治疗前哮喘患者血清胰岛素含量和胰岛素受体含量均高于健康人,经1个月的糖皮质激素治疗,血清胰岛素含量和胰岛素受体含量明显降低,与治疗前相比差异有统计意义(P<0.05)。结论糖皮质激素可有效改善哮喘患者肺功能,调节其胰岛素及胰岛素受体表达。

Objective To analyze the effect of glucocorticoid therapy on insulin receptor expression in patients with asthma and. Methods Totally 30 eases of bronchial asthma patients in our hospital, observation group, given patients one month of continuous glucocorticoid therapy, measured fasting serum glucose levels and insulin levels before and after treatment, and the use of enzyme - linked immunosorbent assay the patient＇s serum levels of soluble insulin receptor were measured and compared with healthy subjects were treated （control group） were compared. Results Before treatment serum insulin levels and insulin receptor levels in asthmatic patients than in healthy people, after glucocorticoid treatment a month, serum insulin levels and insulin receptors were significantly reduced compared with pre - treatment difference was statistically significant （P 〈 0. 05 ）. Conclusion Giucoeortieoids can improve lung function in patients with asthma, adjust their insulin and insulin receptor expression.