雌孕激素联合疗法治疗青春期功能失调性子宫出血的疗效分析

Efficacy of combination of estrogen plus progesterone for dysfunctional uterine bleeding at puberty

目的探讨雌孕激素联合疗法治疗青春期功能失调性子宫出血(DUB)的疗效。方法回顾分析2010年1月—2013年7月尉氏县中医院收治的119例青春期DUB患者的临床资料,根据治疗方案将上述患者分为观察组(64例)与对照组(55例),止血分别采用去氧孕烯炔雌醇、戊酸雌二醇。所有患者调节月经周期均采用黄体酮。结果 1观察组出血控制时间、完全止血时间显著低于对照组,差异有统计学意义(P<0.05)。2观察组调经效果显著优于对照组,差异有统计学意义(P<0.05)。3两组患者不良反应发生率相比差异无统计学意义(P>0.05)。结论雌孕激素联合疗法治疗青春期DUB的疗效确切、安全性良好,值得临床推广。

Objective To investigate the efficacy of combination of estrogen plus progesterone in the treatment of dysfunctional uterine bleeding（UDB） at puberty. Methods The clinical data of 119 cases of UDB at puberty admitted into our hospital from January 2010 to July 2013 were analyzed retrospectively. According to their therapeutic regimen, these patients were divided into observation group（64 cases） and control group（55 cases） , which received desogestrel - ethinyl estradiol and estradiol valerate for hemostasis respectively. Moreover, all patients was given progesterone for menstrual regulation. Results （1）The bleeding - control time and complete - hemostasis time in observation group were significantly lower than those in control group respectively（ P 〈 0. 05 ）.（2）The menstrual - regulation efficacy in observation group was significantly better than that in control group（ P 〈 0. 05 ）. （3）There was no significant difference in the incidence of adverse reactions between 2 groups （P 〉 0. 05）. Conclusion The combination of estrogen plus progesterone in the treatment of UDB at puberty shows good efficacy and safety, which is worthy of being popularized clinically.