精神分裂症人群戊型肝炎感染状况调查

Investigation on the infection status of hepatitis E virus in schizophrenia patients

目的：调查研究精神分裂症人群戊型肝炎的感染状况。方法对1649例精神分裂症患者进行现况调查。收集患者血清，采用ELISA方法进行戊型肝炎病毒（HEV）-IgG以及HEV-IgM抗体的检测，采用Logistic回归方法分析抗体阳性率与性别、年龄、病程以及各生化指标之间的相关性。结果精神分裂症人群HEV-IgG抗体阳性率为33.54%。随着年龄的增加，IgG抗体阳性率逐渐升高，Logistic分析结果显示，以9-20岁年龄组为参照，〉20-30岁、〉30-40岁、〉40-50岁以及〉50岁组的HEV-IgG阳性率OR值（95%CI）分别为1.45（0.94，2.24）（P=0.096）、3.20（2.05，4.99）（P〈0.001）、3.22（2.03，5.11）（P〈0.001）和5.54（3.34，9.21）（P〈0.001）。不同的性别、不同病程HEV-IgG阳性率差异无统计学意义（P〉0.05）。以正常组为参照，谷氨酰转肽酶升高组OR值（95%CI）为1.87（1.12，3.12）（P=0.016）。IgM抗体阳性者13人，且均伴有IgG抗体阳性。结论精神分裂症人群HEV感染率较高，应采取相应措施对该人群进行HEV预防，从而从源头上降低整个人群HEV的发病率。

Objective To investigate the infection status of hepatitis E virus （HEV） in schizophrenia patients. Methods In this cross-sectional study, 1649 schizophrenia patients were recruited. The serum samples were collected. Anti-HEV IgG and IgM were tested by ELISA method. Logistic regression analysis was used to calculate the relationship between gender, age, the duration of schizophrenia, lab test and the positivity of the antibodies. Results 33.54% of the total subjects were anti-HEV IgG positive. The multivariable adjusted ORs （95% CI） of risk of the positivity of anti-HEV IgG were 1.45 （0.94, 2.24） （P=0.096）, 3.20 （2.05, 4.99） （P〈0.001）, 3.22 （2.03, 5.11） （P〈0.001） and 5.54 （3.34, 9.21） （P〈 0.001） for the group of the age 〉20-30,〉30-40, 〉40-50 and〉50, compared to the group of the age 9-20. There was no significant difference between gender, duration and the positivity of anti-HEV IgG （P〉0.05）. Compared to nor-mal group, the positivity of anti-HEV IgG was significantly higher in the higher GGT group （OR = 1.87, 95%CI（1.12,3.12）, P= 0.016）. IgG and IgM were coexisted in 13 individuals. Conclusion This study indicates that the infection status in schizophrenia is serious. Effective prevention strategies are required in future for reducing HEV transmission in schizophrenic patients, in order to reduce the incidence of whole human beings.