益生菌对单纯性肥胖儿童瘦素、脂联素及血脂水平影响的临床观察

The effects of probiotics on adiponectin , leptin and blood fat of simple obesity children

目的 观察益生菌干预前后单纯肥胖症儿童血清中瘦素、脂联素、血脂、体重指数的变化,探讨其临床意义.方法 依据儿童单纯肥胖症诊断标准选取80名患儿,各40名,平均分为两组,均正常饮食,治疗组给予双歧杆菌,乳杆菌和嗜热链球菌口服15天.分别于治疗前及治疗后一个月计算患儿体重指数,检测血清瘦素、脂联素及血脂,SPSS16.0统计软件进行分析.结果 治疗组体重指数及甘油三酯,总胆固醇,低密度脂蛋白水平下降,高密度脂蛋白升高,差异无统计学意义（P＞0.05）;干预后治疗组瘦素水平降低（5.72 ±0.39比8.53 ±0.37）,脂联素水平增高（10.15±0.48比8.81±0.37）,两组之间差异有统计学意义（P＜0.05）.结论 益生菌能够降低瘦素水平,升高脂联素水平.益生菌口服可能成为治疗单纯性肥胖症的新方法.

Objective To observe the levels of adiponection,leptin,blood fat and body mass index （BMI） after the probiotics intervention.Method We assessed the levels of adiponection,leptin,blood fat and BMI in 80 simple obesity children.They were divided into 2 groups.There were 20 boys and girls in each group.One group of children were given bifidobacterium,lactobacillus and streptococcus thermophilus 15 days.Results The levels of BMI and TG,TC,LDL-C of treatment group decreased.The levels of HDL-Cof treatment increased.But there were no significant difference between two groups （P ＞ 0.05）.The levels of leptin （5.72 ± 0.39 vs 8.53 ±0.37） in treatment group decreased.The levels of adiponection （10.15 ±0.48 vs 8.81 ±0.37） Increased.There were significant difference between two groups （P ＜ 0.05）.Conclusions Probiotics could decrease the levels of leptin and increase the levels of adiponection.Probiotics could become a new method to treat the simple obesity.