c-Myc、SIRT1、acetyl-p53在乳腺癌中的表达及其对预后的影响

Expression of c-Myc, SIRT1 and acetyl-p53 in breast carcinoma and prognostic significance

目的:探讨c-Myc、SIRT1及acetyl-p53蛋白在乳腺癌中的表达及其对预后的影响。方法:应用免疫组织化学方法检测90例乳腺癌和30例乳腺增生症中的c-Myc、SIRT1(Sirtuin type 1)、acetyl-p53蛋白表达,结合临床病理资料和随访资料,进行预后分析。结果:c-Myc阳性组乳腺癌患者的5年无瘤生存率和5年总生存率(分别为5 9.0%/6 7.2%)低于c-M y c阴性组(分别为8 6.2%/8 6.2%),S I RT 1阳性组乳腺癌患者的5年无瘤生存率和5年总生存率(分别为5 6.1%/6 4.9%)低于S I RT 1阴性组(87.9%/87.9%);acetyl-p53阳性组乳腺癌患者的5年无瘤生存率和5年总生存率(分别为86.7%/86.7%)高于acetyl-p53阴性组(分别为58.3%/66.7%),差异均有统计学意义(P<0.05)。结论:c-Myc及SIRT1蛋白高表达的乳腺癌患者预后差,而acetyl-p53蛋白高表达的乳腺癌患者预后好。

Objective： To study the correlation between c-Myc, Sirtuin type 1（SIRT1）, acetyl-p53 protein and the prognosis of breast carcinoma. Methods： c-Myc, SIRT1 and acetyl-p53 protein of breast carcinoma and breast adenosis were detected by immunohistochemical staining. And combined with follow-up data, statistical analysis was performed to study the prognosis. Results： C-Myc positive breast carcinoma patients, 5-year disease-free survival rate and 5-year overall survival rate（59.0%/59.0%, respectively） is lower than c-Myc negative ones,（86.2%/86.2%, respectively）. And SIRT1 positive breast cancer patients, 5-year disease-free suvival rate and 5-year overall survival rate（56.1%/56.1%, respectively） is lower than SIRT1 negative ones,（87.9%/87.9%, respectively）. However, Acetyl-p53 positive breast carcinoma patients, 5-year disease-free survival rate and 5-year overall survival rate（86.7%/86.7%, respectively） is higher than the acetyl-p53 negative ones,（58.3%/66.7% respectively）. All the difference had statistical significance（P〈0.05）. Conclusion： Those breast carcinoma patients with c-Myc and SIRT1 protein high expression had a poor prognosis. However, those breast patients with high acetyl-p53 protein expression had a good prognosis.